20.500.12556/RUL-99026 Numerično določanje elektromagnetnih količin pri elektroporaciji z izmeničnim magnetnim poljem Numerical computation of electromagnetic fields in electroporation induced by time-varying magnetic field Elektroporacija je pojav, pri katerem pride do povecanja prepustnosti celicne membrane zaradi izpostavitve celice elektricnemu polju. Elektricno polje v tkivu obicajno vzpostavimo preko elektrod, ki jih namestimo v okolico ciljnega tkiva. Ko pa je ciljno obmocje locirano izven neposrednega dosega elektrod, je potreben invaziven poseg vstavitve elektrod, kar poveca zahtevnost same izvedbe terapije z elektroporacijo. Ena izmed možnih, a žal še ne dovolj raziskanih neinvazivnih metod, je vzpostavitev elektricnega polja v tkivu z uporabo izmenicnega magnetnega polja. V zakljucnem delu je predstavljen numericni model, ki omogoca preucevanje gostote magnetnega pretoka, induciranega elektricnega polja in segrevanja tuljave zaradi elektricnega toka. Rezultate numericnega modeliranja smo potrdili z eksperimentalnimi meritvami. Najvecje polje gostote magnetnega pretoka pri uporabljeni tuljavi znaša 0,80 T in velikostjo elektricnega polja 158 V/m. Tuljava se med dovajanjem 500 pulzov segreje za 15,1 +- 0,3 C. V delu je predstavljena tudi nova izvedba tuljave z 20 % vecjo gostoto magnetnega pretoka, vendar je pri tem višja tudi koncna temperatura tuljave. Electroporation is a phenomenon in which cell membrane permeability increases due to cell exposure to the electric field. The electric field in the tissue is usually established via electrodes, which are placed on the surrounding tissue. However, when the target area is located outside of the reach of electrodes, an invasive insertion of electrodes is required, which increases the complexity of the electroporation therapy itself. One of the possible, but unfortunately not yet well researched of non-invasive methods, is establishment of an electric field in tissue using an alternating magnetic field. In this paper, a numerical model is presented which allows the study of the magnetic flux density, the induced electric field, and the heating of the coil due to the applied electric current. Results have been confirmed by experimental measurements. Maximum induced electric field with used coil design is 158 V/m and maximum magnetic flux density of 0.80 T. The coil is heated by 15.1 +- 0.3 C when supplying 500 pulses to it. The proposed geometry of a new coil reaches a 20 % higher magnetic flux density, however heating of the coil is also higher. elektroporacija magneto-poracija numericno modeliranje tuljave meritve magnetnega polja inducirano elektricno polje electroporation magneto-poration numerical moddeling of coil measurements of magnetic field induced electrical fied true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2017-12-21 10:50:02 2017-12-21 10:50:04 2022-08-16 10:29:04 0000-00-00 00:00:00 2017 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1970-01-01 40941 Pocervina_Blaz_-_Numericno_dolocanje_elektromagnetnih_kolicin_pri_elektroporaciji_z_izmenicnim_m.pdf Pocervina_Blaz_-_Numericno_dolocanje_elektromagnetnih_kolicin_pri_elektroporaciji_z_izmenicnim_m.pdf 1 02E21871D590455404D8D40975A285C9 e5889d1b8c0ea57162654c5e6d1a1faeb579027fbc5a89e2c527b37c59c0b07e 7ab58de6-a1b4-11eb-a523-00155dcfd717 20.500.12556/rul/51eebe88-789c-4be0-8e31-b05098827e67 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=108373 Fakulteta za elektrotehniko 0 0 0