20.500.12556/RUL-95631 Metabolizem triptofana Tryptophan metabolism Namen tega diplomskega dela je splošen pregled metabolizma triptofana in vpliv njegovih metabolitov na funkcije človeškega telesa. L-triptofan je ena od osmih esencialnih aminokislin, ki je človeško telo samo ne more sintetizirati, zato je edini vir preskrba z ustrezno prehrano. Poleg ustreznega dnevnega vnosa triptofana je potrebno upoštevati tudi številne faktorje, ki vplivajo na povečevanje ali zmanjševanje prostega triptofana, ki je na voljo za prehod krvno-možganske pregrade. Na področju EU je omogočena tudi prodaja triptofana kot prehranskega dopolnila, ki je sicer popolnoma varen, vendar lahko dnevne količine vnesenega triptofana pri nekaterih posameznikih nekajkrat presegajo priporočen dnevni vnos in vodijo do t. i. serotoninskega sindroma. Triptofan se kot aminokislina v zelo majhnem obsegu vključuje v telesu lastne beljakovine, hkrati pa je prekurzor mnogih bioaktivnih molekul v našem telesu. V encimsko kataliziranih reakcijah se pretvarja v serotonin, melatonin in različne metabolite kinureninske poti. Molekule, ki se tvorijo v metabolizmu triptofana, imajo hormonsko in imunomodulatorno funkcijo, zato ima triptofan pomemben vpliv na delovanje različnih organov, psihološka stanja in vnetne procese v organizmu. Zelo velik napredek v razumevanju metabolizma so raziskovalci dosegli predvsem z raziskovanjem osi možgani-črevesje-mikrobiota, ki direktno in indirektno vpliva na funkcije centralnega živčnega sistema. Aim of the thesis is to give an overview of tryptophan metabolism and present the impact of tryptophan’s metabolites on the functions of the human body. L-tryptophan is one of the eight essential amino acids that cannot be synthesised within the human body and its only source is appropriate diet. Beside the adequate daily intake of tryptophan, many other factors affecting the increase or decrease of free tryptophan that crosses the blood-brain barrier have to be taken into account. In the EU, tryptophan can be sold as a dietary supplement that is completely safe to use. However, if the daily intake exceeds the recommended levels, some individuals may develop the so called serotonin syndrome. To a small extent, the amino acid tryptophane is incorporated into proteins of the human body and is a precursor of numerous bioactive molecules. It also transforms into serotonin, melatonin and metabolites of the kynurenine pathway during enzyme-catalyzed reactions. The molecules that develop inside tryptophan metabolism have a hormonal and immunomodulatory function. This is why tryptophane has an important impact on the functioning of different organs, various psychological conditions and inflammation processes of the organism. Researchers have made a significant step forward in understanding metabolism, mainly through research on the brain gut microbiota axis that has a direct and indirect impact on the functions of the central nervous system. aminokisline triptofan metabolizem triptofana serotonin kinurenin prehranska dopolnila serotoninski sindrom amino acids tryptophan tryptophan metabolism serotonin kynurenine dietary supplements serotonin syndrome true false false [R. Mejaš] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2017-09-21 07:53:02 2017-09-21 07:53:04 2022-08-10 06:39:00 0000-00-00 00:00:00 2017 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 637.1/.3:613.287:616.34 143398 4836728 1203.pdf 1203.pdf 1 BBB50AE9AA815318198D0163F768A173 1389ba7436c8b2952bd7fa23a832119d32c4ac75ec87db9ace4cbc187517f2c0 ce6c0cc7-a1b3-11eb-a523-00155dcfd717 20.500.12556/rul/7619872d-a817-4801-a85b-768729c2f144 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=104256 Biotehniška fakulteta 0 0 0