20.500.12556/RUL-95069 Uporaba bioloških omrežij za izračun funkcijske obogatenosti skupine genov Gene set function enrichment analysis using biological networks Molekularni biologi in genetiki se dandanes ukvarjajo s proučevanjem zapisa DNA. Pri eksperimentih tipično dobijo podatke, ki se zaradi svoje narave težko interpretirajo. Klasične metode primerjajo eksperimentalno dobljeno skupino genov z znanimi, funkcijsko povezanimi skupinami genov, a pogosto niso uspešne. Izboljšava pristopa je metoda SANTA, ki vrednoti eksperimentalne rezultate na podlagi omrežja genov. Metodo SANTA smo implementirali v sklopu diplome, v dodatku Orange Bioinformatics. Orange je že dobro uveljavljen program za obdelavo podatkov. Dodatek Bioinformatics zavzema specializirane funkcionalnosti za obdelavo genskih podatkov. Dodatek smo obogatili tudi z izboljšanim dostopom do zbirk BioGRID in STRING, ki hranita podatke o eksperimentalno določenih povezavah med geni. Molecular biologists and geneticists are, nowadays, mostly focused on studying and understanding the DNA transcription. The gathered experimental data is difficult to interpret. Classical methods compare the discovered groups of genes with predefined gene sets. Unfortunately, these methods do not perform well. A solution is proposed by the SANTA method, which evaluates the experimental results on discovered gene sets based on known and extensive gene networks. In this thesis, we have implemented the method in Orange Bioinformatics. Orange is a well-known data-analysis programme. The Bioinformatics add-on includes specialised functionality for processing genomic data. Furthermore, we have also enriched its widgets for access to BioGRID and STRING, which store information on functional sets of genes and interactions. Python Orange bioinformatika omrežje SANTA STRING BioGRID Python Orange bioinformatics network SANTA STRING BioGRID true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2017-09-13 13:59:47 2017-09-13 13:59:48 2022-08-10 02:14:11 0000-00-00 00:00:00 2017 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1970-01-01 20164 Cvitkovic_Robert_-_Uporaba_bioloskih_omrezij_za_izracun_funkcijske_obogatenosti_skupine_genov.pdf Cvitkovic_Robert_-_Uporaba_bioloskih_omrezij_za_izracun_funkcijske_obogatenosti_skupine_genov.pdf 1 89CABA95DDA2F3A7E1D45C53ADBAF196 bd281893928fe7b9ae6be3f9244119852241ab74cb45d1c39761a81969c46c77 ab5b4c9f-a1b3-11eb-a523-00155dcfd717 20.500.12556/rul/40c0a6b1-3f0d-47b0-9098-6e886f6ffd83 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=103596 Fakulteta za računalništvo in informatiko 0 0 0