20.500.12556/RUL-72655 Iskanje protimikrobnih snovi, ki jih izločajo bakterije izolirane iz jam diplomsko delo Screening of cave bacteria for antibacterial compounds Glede na vedno hitrejši razvoj večkrat odpornih patogenih bakterij, se je v zadnjih nekaj desetletjih potreba po pridobivanju novih protimikrobnih učinkovin močno povečala. Ravno zato, znanstveniki raziskujejo ekstremna okolja kot so jame, ki bi bile lahko potencialen nov vir antibiotikov. V naši raziskavi smo uporabili osem in sedemdeset izolatov jamskih bakterij, ki so bili pridobljeni iz Pajsarjeve jame pri Vrhniki in ki so jih uvrstili v rodove Streptomyces, Micrococcus, Rhodococcus, Pseudomonas, Agrobacterium, Lysobacter, Bacillus, Sphingomonas in Kocuria. Testirali smo protimikrobno aktivnost jamskih izolatov proti desetim po Gramu pozitivnim in Gramu negativnim rezistentnim indikatorskim sevom. Prav vsak izmed izolatov je zaviral rast vsaj enemu izmed indikatorskih sevov. Tako visok delež sevov z izraženo protimikrobno aktivnostijo nakazuje, da so jame perspektiven vir novih protimikrobnih učinkovin. Considering the pace at which multi-drug resistant pathogenic microorganisms are emerging, there is an increasing need to discover new and more effective antibiotics. To this aim, the scientists are looking for novel microbes in understudied environments, such as caves, that could potentially provide us with new source of antibiotics. The eighty-seven cave bacteria isolates we used in our research, were obtained in Pajsarjeva jama near Vrhnika. We then screened those isolates, against ten Gram positive and Gram negative multidrug resistant strains. Isolates belonged to genera Streptomyces, Micrococcus, Rhodococcus, Pseudomonas, Agrobacterium, Lysobacter, Bacillus, Sphingomonas in Kocuria. Each one of the isolates has exhibited at least one antimicrobal avtivity against multidrug resistant strains. The high proportion of antimicrobial-producing strains suggests that caves may represent a potential reservoir of novel bioactive compounds. protimikrobna aktivnost odpornost izolati indikatorski sev antimicrobal activity true false false P. Petrić] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2015-09-29 05:12:12 2015-09-29 05:12:12 2025-04-17 04:52:17 0000-00-00 00:00:00 2015 0 0 VIII f., 26 str. 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 57(043.2) 10703433 Diplomsko_delo_Patrica_Petric_bi-go.pdf Diplomsko_delo_Patrica_Petric_bi-go.pdf 1 D2B128B9BADBD4BE24F815B046F84C51 eb677ceeaf6e01cbe8ff6786a2dba4aed017ee59132117733ef2c5ed4a4b4f66 67a48eaf-1aa7-11f0-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=204137 Pedagoška fakulteta 0 0 0