20.500.12556/RUL-49107 Interaction between dipolar lipid headgroups and charged nanoparticles mediated by water dipoles and ions In this work, a theoretical model describing the interaction between a positively or negatively charged nanoparticle and neutral zwitterionic lipid bilayers is presented. It is shown that in the close vicinity of the positively charged nanoparticle, the zwitterionic lipid headgroups are less extended in the direction perpendicular to the membrane surface, while in the vicinity of the negatively charged nanoparticle, the headgroups are more extended. This result coincides with the calculated increase in the osmotic pressure between the zwitterionic lipid surface and positively charged nanoparticle and the decrease of osmotic pressure between the zwitterionic lipid surface and the negatively charged nanoparticle. Our theoretical predictions agree well with the experimentally determined fluidity of a lipid bilayer membrane in contact with positively or negatively charged nanoparticles. The prospective significance of the present work is mainly to contribute to better understanding of the interactions of charged nanoparticles with a zwitterionic lipid bilayer, which may be important in the efficient design of the lipid/nanoparticle nanostructures (like liposomes with encapsulated nanoparticles), which have diverse biomedical applications, including targeted therapy (drug delivery) and imaging of cancer cells. charged nanoparticles lipids osmotic pressure dipolar zwitterionic headgroups relative permittivity of water orientational ordering biološke membrane biofizika membrane lipidi nanodelci elektrostatske interakcije true false true Angleški jezik Slovenski jezik Članek v reviji 2015-07-10 15:41:55 2015-07-10 15:41:55 2022-08-01 12:29:35 0000-00-00 00:00:00 2013 0 0 Str. 15312-15329 iss. 8 Vol. 14 2013 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.352:576.314 1422-0067 10.3390/ijms140815312 4257144 2779162 RAZ_Velikonja_Aljaz_2013.pdf RAZ_Velikonja_Aljaz_2013.pdf 1 E1260405EEE8080DAFAF12DD159AAAE6 83ee80ce36e99ae6165943040a4ad930ebe76ea22696a10194181e9da42e9c82 d044fab3-0a56-11ec-a523-00155dcfd717 20.500.12556/rul/1ee92dc5-b35a-45b7-a709-18be48ce779e https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146225 http://www.mdpi.com/1422-0067/14/8/15312 0 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=49118 Biotehniška fakulteta Fakulteta za elektrotehniko Medicinska fakulteta Zdravstvena fakulteta 0 0 0