20.500.12556/RUL-37697 Biological activities of ethanolic extracts from deep-sea Antarctic marine sponges We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth inhibition of laboratory, commensal and clinically and ecologically relevant bacteria. The most prominent activities were associated with the extracts from sponges belonging to the genus Latrunculia, which show all of these activities. While most of these activities are associated to already known secondary metabolites, the extremely strong acetylcholinesterase inhibitory potential appears to be related to a compound unknown to date. Extracts from Tetilla leptoderma, Bathydorus cf. spinosus, Xestospongia sp., Rossella sp., Rossella cf. racovitzae and Halichondria osculum were hemolytic, with the last two also showing moderate cytotoxic potential. The antibacterial tests showed significantly greater activities of the extracts of these Antarctic sponges towards ecologically relevant bacteria from sea water and from Arctic ice. This indicates their ecological relevance for inhibition of bacterial microfouling. Antarctic marine sponges hemolysis antibacterial activity acetylcholinesterase inhibition cytotoxicity true false true Angleški jezik Ni določen Članek v reviji 2015-07-10 13:04:44 2015-07-10 13:04:44 2022-08-01 12:25:01 0000-00-00 00:00:00 2013 0 0 Str. 1126-1139 iss. 4 Vol. 11 2013 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.1 1660-3397 10.3390/md11041126 2762319 23578841 RAZ_Turk_Tom_2013.pdf RAZ_Turk_Tom_2013.pdf 1 2A20E960EDF6EA4B2406C5B29EB24988 07372fa842d4baea5425ac56eeb7296c3477aec690f364afb952d50079c911e2 95268a22-0a5f-11ec-a523-00155dcfd717 20.500.12556/rul/04dbf17f-bdef-4f05-86bd-7b3a6d68acb9 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=146227 http://www.mdpi.com/1660-3397/11/4/1126 0 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=37708 Biotehniška fakulteta Medicinska fakulteta 0 0 0