20.500.12556/RUL-189845 Effect of coronary sinus reducer implantation on aerobic exercise capacity in refractory angina patients - a CROSSROAD Study Coronary sinus reducer (CSR) implantation is a new treatment option for patients with refractory angina pectoris. However, there is no evidence from a randomized trial that would show an improvement in exercise capacity after this treatment. The aim of this study was to evaluate the influence of CSR treatment on maximal oxygen consumption and compare it to a sham procedure. Twenty-five patients with refractory angina pectoris (Canadian Cardiovascular Society (CCS) class II–IV) were randomized to a CSR implantation (n = 13) or a sham procedure (n = 12). At baseline and after 6 months of follow-up, the patients underwent symptom-limited cardiopulmonary exercise testing with an adjusted ramp protocol and assessment of angina pectoris using the CCS scale and Seattle angina pectoris questionnaire (SAQ). In the CSR group, maximal oxygen consumption increased from 15.56 ± 4.05 to 18.4 ± 5.2 mL/kg/min (p = 0.03) but did not change in the sham group (p = 0.53); p for intergroup comparison was 0.03. In contrast, there was no difference in the improvement of the CCS class or SAQ domains. To conclude, in patients with refractory angina and optimized medical therapy, CSR implantation may improve oxygen consumption beyond that of optimal medical therapy. reduktor koronarnega sinusa refraktorna angina poraba kisika coronary sinus reducer refractory angina oxygen consumption reduktor koronarnega sinusa refraktorna angina poraba kisika true false true Angleški jezik Slovenski jezik Članek v reviji 2026-10-17 09:53:38 2026-10-19 08:53:57 2026-10-20 04:38:16 0000-00-00 00:00:00 2023 0 0 8 str. no. 6, art. 235 Vol. 10 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2308-3425 10.3390/jcdd10060235 154515459 RAZ_Mrak_Miha_2023.pdf RAZ_Mrak_Miha_2023.pdf 1 39FA26796528A1BFBAFD285759FE2A33 4ade1c939e9386d4355d53f24a7c46b2227e1d701701a2ae644c096e9b402d89 cea528d8-cb89-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=250815 https://www.mdpi.com/2308-3425/10/6/235/htm 1 b30d9624-c9ff-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=250727 Medicinska fakulteta 0 0 0