20.500.12556/RUL-189760 Prognostic factors for restenosis of superficial femoral artery after endovascular treatment High incidence of superficial femoral artery (SFA) restenosis after percutaneous transluminal angioplasty (PTA) poses a persistent challenge in peripheral arterial disease (PAD) treatment. We studied how the patients' and lesions' characteristics, thrombin generation, overall haemostatic potential (OHP), and single nucleotide polymorphisms (SNPs) of the NR4A2 and PECAM1 genes affected the likelihood of restenosis. In total, 206 consecutive PAD patients with limiting intermittent claudication due to SFA stenosis who were treated with balloon angioplasty with bailout stenting when necessary were included. Patients' clinical status and patency of the treated arterial segment on ultrasound examination were assessed 1, 6, and 12 months after the procedure. Restenosis occurred in 45% of patients, with less than 20% of all patients experiencing symptoms. In the multivariate analysis, predictors of restenosis proved to be poor infrapopliteal runoff, higher lesion complexity, absence of treated arterial hypertension, delayed lag phase in thrombin generation, and higher contribution of plasma extracellular vesicles to thrombin concentration. Poor infrapopliteal runoff increased the risk of restenosis in the first 6 months, but not later. The negative effect of poor infrapopliteal runoff on SFA patency opens questions about the potential benefits of simultaneous revascularisation of below-knee arteries along with SFA revascularisation. endovascular procedures femoral artery vascular patency hemostasis polymorphism endovaskularni postopki femoralna arterija vaskularna prehodnost hemostaza polimorfizem true false true Angleški jezik Slovenski jezik Članek v reviji 2026-10-15 08:04:46 2026-10-16 12:30:40 2026-10-17 04:16:13 0000-00-00 00:00:00 2023 0 0 13 str. iss. 19, art. 6343 Vol. 12 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2077-0383 10.3390/jcm12196343 169180931 RAZ_Boc_Vinko_2023.pdf RAZ_Boc_Vinko_2023.pdf 1 8212827EA52875CB31F6332A6CB3DFDC d9ee26e3735c9e0e1666283a8810d8a5b3775b3f23d8caf8673e9ba365c0762e 1406d6f2-c94c-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=250682 https://www.mdpi.com/2077-0383/12/19/6343 1 2a725d6e-c85e-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=250552 Fakulteta za farmacijo Medicinska fakulteta 0 0 0