20.500.12556/RUL-188592 Giant cutaneous melanoma presenting with hemorrhagic complications Giant cutaneous melanoma is a rare presentation characterized by significant morbidity and mortality. We report the case of a 45-year-old male presenting with an acute life-threatening hemorrhage from a giant melanoma on his right thigh. The tumor, measuring 90 × 50 × 85 mm, was immediately excised under local anesthesia to achieve hemostasis. The patient exhibited acute anemia and required postoperative blood transfusion. Histopathological analysis confirmed superficial spreading melanoma with a Breslow thickness of 85.0 mm and extensive ulceration. Genetic testing identified critical mutations, including BRAFV600D and alterations involving the ARID2, CDKN2A/B, AKT3, PTEN, and HRAS genes. Remarkably, no metastatic disease was detected upon thorough diagnostic evaluation. The patient received adjuvant immunotherapy with programmed cell death-1 inhibitors. Six months after the procedure, he remains free of metastasis. This case underscores the urgent need for timely recognition and intervention in giant melanoma with acute complications. It also highlights the effectiveness of modern adjuvant therapies in improving prognosis. dermatologic surgery dermatopathology melanoma skin cancer true false true Angleški jezik Ni določen Na pristajalni strani revije: https://acta-apa.mf.uni-lj.si/submissions.php navedeno, da je članek objavljen z licenco CC BY 4.0: https://creativecommons.org/licenses/by/4.0/. Članek v reviji 2026-09-24 09:07:45 2026-09-24 09:07:49 2026-09-26 03:32:40 0000-00-00 00:00:00 2026 0 0 Str. 129-132 iss. 2 Vol. 35 Mar. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 617 1318-4458 10.15570/actaapa.2026.1 283158531 RAZ_Lovsin_Klemen_2026.pdf RAZ_Lovsin_Klemen_2026.pdf 1 20ADCDD157EB6A4083BF813C9A257552 e61c25e04c633447632d9110fabb2a486f2001f63ef5797b4e2312c1ca3a65e7 9541610d-b7e6-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=248855 https://acta-apa.mf.uni-lj.si/journals/acta-dermatovenerol-apa/papers/10.15570/actaapa.2026.1/actaapa.2026.1.pdf 0 fb63bb91-b7e6-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=248856 Medicinska fakulteta 0 0 0