20.500.12556/RUL-187480 Analiza procesa filmskega oblaganja delno obložene tablete Process analysis of film coating of a partially coated tablet Filmsko oblaganje tablet predstavlja poglavitno dejavnost farmacevtskih družb za izboljšanje lastnosti tablet, kot so učinkovitost dostave učinkovin, odstranjevanje neprijetnega vonja, okusa ter izboljšave stabilnosti učinkovin. V nalogi smo s pomočjo eksperimentalne proge, ki je vključevala mizico za postavitev tablete ter dozirnik kapljic, izvedli študijo kapljičastega pronicanja učinkovine v tableto. V posebni komori smo simulirali pogoje iz farmacevtskih oblagalnikov ter izvedli meritve omočene površine, širine in globine pronicanja, kontaktnega kota kapljice ob stiku s površino, analizo hrapavosti površin ter debeline obloge. Obravnavali smo vpliv debeline posamezne nanešene obloge na pronicanje kapljice v tableto in širjenje kapljice po površini. Film coating of tablets is an important process in the pharmaceutical industry for improving tablet properties, such as the efficiency of drug delivery, masking unpleasant odours and tastes, and enhancing drug stability. In this thesis, an experimental setup consisting of a tablet positioning stage and a droplet dispenser was used to investigate the penetration of a drug solution into tablets. In a separate experimental chamber, conditions encountered in pharmaceutical coating equipment were simulated, and measurements of the wetted surface area, penetration width and depth, droplet contact angle upon contact with the surface, surface roughness, and coating thickness were performed. The influence of coating thickness on liquid penetration into the tablet and droplet spreading over the surface was investigated. proces filmsko oblaganje tableta kapljičasto nanašanje delno obložene tablete process film coating tablet droplet application partially coated tablets true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2026-09-11 08:31:02 2026-09-11 08:31:03 2026-09-12 04:29:27 0000-00-00 00:00:00 2026 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1970-01-01 289954 49390.pdf 49390.pdf 1 925C9057B6A2CEF30CC58AF2B0291482 f91176b27b803a25e16f8ce12439e797ea945088bf016b31cd744e579ed7ddaf 5611d988-adaa-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=247114 Fakulteta za strojništvo 0 0 0