20.500.12556/RUL-187064 Protiglivne lastnosti bakterij rodu Bacillus in njihova uporaba v medicini Antifungal Properties of Bacillus Genus Bacteria and Their Application in Medicine Okužbe s patogenimi glivami predstavljajo veliko težavo v sodobnem svetu. Najpogosteje prizadenejo ljudi z oslabljenim imunskim sistemom, ki se ob tovrstnih okužbah velikokrat znajdejo v smrtni nevarnosti. Letno za glivnimi infekcijami zboli približno milijone ljudi, njihovo zdravljenje, ki je povezano s številnimi izzivi zaradi podobnosti glivnih celic s človeškimi, pa predstavlja veliko ekonomsko breme za zdravstveni sistem. Zato je razvoj novih terapij zdravljenja glivnih infekcij ljudi, nujen za spopadanje z njimi. Pomemben, a preslabo raziskan vir protiglivnih metabolitov predstavljajo bakterije rodu Bacillus. Med njih sodijo številni lipopeptidi, encimi, bakteriocini in hlapne organske spojine. Na glivne celice lahko delujejo s poškodbo celične membrane ali celične stene, s povzročitvijo znotrajceličnih poškodb, z zaviranjem adhezije, filamentacije, invazije, izločanja hidrolaz in tvorbe ter širjenja biofilma. Diplomsko delo temelji na sistematičnem pregledu znanstvene literature, predvsem in vitro raziskav protiglivnih metabolitov bakterij rodu Bacillus in njihovih mehanizmov delovanja. Hkrati tudi opozarja na omejitve dosedanjih rezultatov raziskav, potrebne prihodnje raziskave na tem področju in pomembnost razvoja novih terapij zdravljenja glivnih infekcij, katerih obetaven vir predstavljajo prav bioaktivni sekundarni metaboliti bakterij rodu Bacillus. Pathogenic fungal infections represent a major challenge in modern medicine. They primarily affect immunocompromised individuals, who often face a high risk of mortality because of these infections. Millions of people develop fungal infections each year and their treatment poses a considerable economic burden on healthcare systems due to the close similarity between fungal and human cells, which limits therapeutic options. Therefore, the development of novel therapies for the treatment of human fungal infections is essential. Bacteria of the genus Bacillus represent an important yet insufficiently explored source of antifungal metabolites. These include lipopeptides, enzymes, bacteriocins, and volatile organic compounds. They exert antifungal activity by disrupting the fungal cell membrane or cell wall, inducing intracellular damage, and inhibiting adhesion, filamentation, invasion, hydrolase secretion, as well as biofilm formation and dispersal. This bachelor’s thesis is based on a systematic review of the scientific literature, focusing primarily on in vitro studies investigating antifungal metabolites produced by Bacillus species and their mechanisms of action. Furthermore, it highlights the limitations of current research, the need for future investigations in this field, and the importance of developing novel antifungal therapies, for which bioactive secondary metabolites produced by Bacillus species represent a promising source. bakterije rodu Bacillus protiglivni metaboliti mikoze mehanizmi protiglivnega delovanja Bacillus spp. antifungal metabolites mycoses mechanisms of antifungal action true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2026-09-09 07:16:42 2026-09-09 07:16:50 2026-09-10 10:07:05 0000-00-00 00:00:00 2026 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 287551 290616835 61051.pdf 61051.pdf 1 CE76B6065DD2C20FEC0AF638AE37EC74 043ecc947e94b21f1114facd70a1011444c1c1e79f6011b61657a7598167ccd7 a3e6324e-ac0d-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=246500 Biotehniška fakulteta 0 0 0