20.500.12556/RUL-186936 Application of LC‑MS/MS methods and risk assessment for selected emerging contaminants and their transformation products in a sub‑Adriatic river system The present study investigates solid-phase extraction (SPE) followed by LC-MS/MS for the analysis of contaminants of emerging concern (CECs) and transformation products (TPs) in the Slovenian-Italian Vipava river system (part of the Adriatic Sea catchment). The adapted method enabled quantitative analysis of 13 various CECs and qualitative analysis of 2 UV filters. SPE recoveries ranged from 17 to 116%, LODs from 0.11 to 5.9 ng L$^{−1}$, and overall %RSDs were below 20%. A separate LC-MS/MS method enabled analysis of 42 suspect TPs. Total-ion current LC-MS chromatograms (chemical fingerprints) for river water extracts were also recorded to observe changes along the river course. Ten CECs were frequently detected, and two rosuvastatin TPs, ROS349 and ROS481, were both identified by LC-MS/MS and confirmed with LC-QTOF. Caffeine was the most frequently detected analyte, with average concentrations around 100 ng L$^{−1}$, and was even detected in spring water from karst aquifers. Most other CECs were present at higher concentrations near wastewater treatment plants (WWTPs) and landfills. The influence of these two facilities was also observed through chemical fingerprinting. Acesulfame and tris(2-ethylhexyl) phosphate occasionally exceeded 100 ng L$^{−1}$. The latter, along with diflufenican (maximum 67 ng L$^{−1}$), resulted in elevated environmental risk quotients. Avobenzone and octocrylene showed higher abundance near WWTPs. Telmisartan and rosuvastatin were quantified at concentrations below 73 and 18 ng L$^{−1}$, respectively. Overall, this study expands knowledge of anthropogenic stress on the surface waters in the part of the sub-Adriatic region. chemical fingerprinting emerging pollutants solid-phase extraction spatial trends surface water liquid chromatography mass spectrometry transformation products kemijsko profiliranje emergentna onesnaževala novodobna onesnaževala ekstrakcija na trdno fazo prostorska porazdelitev površinska voda tekočinska kromatografija masna spektrometrija transformacijski produkti true false true Angleški jezik Slovenski jezik Članek v reviji 2026-09-07 12:36:51 2026-09-07 12:36:54 2026-09-08 04:19:40 0000-00-00 00:00:00 2026 0 0 19 str. iss. 7, art. 683 Vol. 198 Jul. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 543.544.5:543.51:502.51:504.5 1573-2959 10.1007/s10661-026-15437-4 280652547 RAZ_Kravos_Aleksander_2026.pdf RAZ_Kravos_Aleksander_2026.pdf 1 A9F54125CF1FF281DBA3D8F148583D48 45d05cfa165b99e2781e2caf5f911a32c0e48deb1df976c23493115aae49f0ec c06ea278-aaa8-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=246335 https://link.springer.com/article/10.1007/s10661-026-15437-4 1 09b12b62-aaa8-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=246333 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0