20.500.12556/RUL-186737 Epigenetic alterations in head and neck cancer a brief update DNA methylation of tumour suppressor genes is the most well-studied epigenetic alterations in head and neck cancer. The tumour suppressor genes CDKN2A, RASSF1, and TIMP3 are the most frequently investigated, but the methylation status has been analysed in more than another dozen genes, for example MGMT. In oral squamous cell carcinoma (OSCC) methylation of MGMT, DAPK, and CDKN2A are promising biomarkers of prognostic value. Inhibition of LSD1, encoding a histone demethylase, attenuates the development and growth of OSCC. Methylation of TIMP3 in sinonasal adenocarcinoma (intestinal type) is associated with a significant worse survival, an association not seen in sinonasal squamous cell carcinoma. Olfactory neuroblastoma can be distinguished into four unique subgroups by methylation profiling. Methylation of RASSF1 is seen in NUT carcinoma, and significantly higher RASSF1 methylation is found in SMARCB1/INI1-deficient tumours compared to the less aggressive SMARCB1/INI-proficient tumours. Genome-wide methylation profiling in combination with IDH2 mutation status suggests that tumours with undifferentiable SNUC morphology can be classified into for subgroups. Most salivary gland carcinoma subtypes have specific epigenetic signatures. Four of the most common subtypes, adenoid cystic carcinoma (ADCC), mucoepidermoid carcinoma (MEC), acinic cell carcinoma (ACC), and carcinoma ex pleomorphic adenoma (CXPA) have all methylation of RASSF1A, two (MEC and ADCC) also of TIMP3 and two (MEC and CXPA) of p16INK4a. A methylation landscape of 20 salivary gland tumours (SGTs) is nowadays available. clinical implications epigenetics head and neck cancer methylation tumour suppressor genes klinični izid epigenetika novotvorbe glave in vratu metilacija geni za zaviranje tumorjev true false true Angleški jezik Slovenski jezik Članek v reviji 2026-09-04 12:13:57 2026-09-04 12:14:03 2026-09-06 03:37:30 0000-00-00 00:00:00 2026 0 0 Str. 289–295 iss. 2 Vol. 489 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 1432-2307 10.1007/s00428-026-04528-9 281121795 RAZ_Hellquist_Henrik_2026.pdf RAZ_Hellquist_Henrik_2026.pdf 1 2F5318DC777AC3FD801CAA1DBACED6B4 54199c7555961e4bab9c9b76536631ae879d9bd76ed5c4a90d9d57f564a8fcdc 00025ffb-a84a-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=246094 https://link.springer.com/article/10.1007/s00428-026-04528-9 1 5c113f8b-a849-11f1-8bc5-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=246093 Medicinska fakulteta 0 0 0