20.500.12556/RUL-186323 Terapevtski pristopi pri uporabi regulatornih celic T Therapeutic strategies using regulatory T-cells Diplomska naloga opisuje vlogo regulatornih celic Treg pri vzdrževanju imunske homeostaze in njihovo vlogo pri avtoimunskih boleznih, razvoju raka in zavrnitvi presadkov po transplantacijah. Namen dela je analizirati mehanizme, s katerimi Treg bodisi ščitijo tkiva bodisi prispevajo k napredovanju bolezni, in oceniti njihov terapevtski potencial. V diplomski nalogi sem pregledala sodobne terapevtske pristope, vključno z adoptivnim prenosom Treg in uporabo gensko modificiranih Treg ter analizirala fiziologijo in mehanizme delovanja Treg. Ugotovitve kažejo, da natančno razumevanje delovanja Treg omogoča razvoj tarčnih terapij, ki so ključne za optimizacijo zdravljenja onkoloških in avtoimunskih bolezni ter izboljšanje uspešnosti transplantacij. Čeprav so trenutne terapije večinoma v fazi predkliničnih in zgodnjih kliničnih študij, rezultati kažejo na njihov potencial za prihodnjo medicinsko prakso. Tovrstne metode odpirajo nove možnosti za razvoj terapevtskih pristopov, saj omogočajo ciljno uravnavanje kompleksnega imunskega odziva. Bachelor's thesis describes the role of regulatory cells Treg in maintaining immune homeostasis and their involvement in the development of autoimmune diseases, cancer, and transplant rejection. The aim of the thesis is to analyse the mechanisms by which Treg cells either protect tissues or contribute to disease progression, and to evaluate their therapeutic potential. In thesis, I reviewed current therapeutic approaches, including adoptive Treg cell transfer and the use of genetically modified Treg cells, and analysed the physiology as well as mechanisms of Treg cell function. The findings indicate that a detailed understanding of Treg cell function enables the development of targeted therapies, which are essential for optimizing the treatment of oncological and autoimmune diseases and improving transplantation outcomes. Although current therapies are mostly in the preclinical and early clinical trial stages, the results confirm their potential for future medical practice. These methods open up new possibilities for the development of therapeutic strategies by enabling targeted modulation of complex immune response. Treg imunska toleranca imunoterapija avtoimunske bolezni transplantacije rak CAR-Treg TCR-Treg FOXP3 Treg immune tolerance immunotherapy autoimmune diseases transplantation cancer CAR-Treg TCR-Treg true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2026-08-31 07:17:23 2026-08-31 07:17:30 2026-09-03 04:37:13 0000-00-00 00:00:00 2026 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 286505 289786371 60697.pdf 60697.pdf 1 E4FEBA7377B81C28064075DF6CE977B0 c6abdc4d55aeda533fbbc9927826a74658e84cb7001eb8d29b3d73bba3e34add d6bc02b6-a4fa-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=245474 Biotehniška fakulteta 0 0 0