20.500.12556/RUL-186232 Repositioning candidate gene approaches in the post-GWAS era a clinical perspective from psychiatric pharmacogenetics The clinical adoption of pharmacogenetics has advanced unevenly despite rapid progress in genomic discovery. Genome-wide association studies and next-generation sequencing have substantially improved our understanding of the polygenic and regulatory architecture of complex diseases, yet translating these insights into clinically actionable pharmacogenetic strategies remains challenging. In this opinion article, we argue that targeted genetic approaches, traditionally represented by candidate gene association studies, should be reconsidered within a modern genomic framework. While such approaches proved limited as discovery tools for complex disease risk, they may retain translational value when integrated with genome-wide evidence and multi-omics prioritization. In pharmacogenetics, pathway-focused investigations and targeted validation studies can help bridge the gap between large-scale genomic discovery and clinical implementation. Within this framework, pharmacokinetic pharmacogenes (e.g., CYP2D6, CYP2C19) and pharmacodynamic phenotypes (e.g., treatment response, antipsychotic-induced weight gain) represent fundamentally different translational challenges, differing in effect size, biological complexity, and clinical readiness. We propose that the strategic integration of genome-wide analyses, sequencing, multi-omics data, and hypothesis-driven genetic studies may accelerate the clinical adoption of pharmacogenetics and contribute to more effective precision medicine in psychiatry. candidate gene studies GWAS pharmacogenomics pharmacogenetics precision psychiatry študije kandidatnih genov genomske asociacijske študije farmakogenomika farmakogenetika natančna psihiatrija personalizirana psihiatrija true false true Angleški jezik Slovenski jezik Članek v reviji 2026-08-28 13:36:34 2026-08-28 13:36:42 2026-08-29 04:41:00 0000-00-00 00:00:00 2026 0 0 9 str. Vol. 17, art.1828563 Avg. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.89 1664-8021 10.3389/fgene.2026.1828563 288888067 RAZ_Pjevac_Milica_2026.pdf RAZ_Pjevac_Milica_2026.pdf 1 55728819688BF5FFBB470D9048AEC662 5ba245aa03ceb1998132f9789f8d7183f92c04a0ff80e7e4dafaea89df2482d2 ddc2beea-a2d4-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=245360 https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1828563/full 1 59b24189-a2d4-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=245359 Medicinska fakulteta 0 0 0