20.500.12556/RUL-185986 Cephapirin usage at dry-off in Holstein and Simmental cows in relation to udder health, parity, and production level Povezanost primjene cefapirina sa zdravljem vimena, paritetom i proizvodnjom mlijeka pri zasušenju krava holštajnske i simentaske pasmine The research aimed to evaluate cephapirin usage at dry-off in Holstein and Simmental dairy cows, with respect to udder health status, parity, and milk production level. The analysis was based on a large dataset derived from routine milk records. The cows were classified by mastitis status (clinical, subclinical, and healthy), parity, and average production level. The results indicate that a considerable proportion of cephapirin was administered unnecessarily to healthy cows, those without clinical signs of mastitis or elevated somatic cell counts. Across both breeds, over 55% of the total antibiotic quantity was used in cows classified as healthy. This practice was especially prevalent among primiparous cows and those in lower production groups, reflecting a widespread reliance on blanket dry cow therapy (BDCT). Furthermore, breed-specific differences were also observed: Holstein cows demonstrated a more pronounced shift toward therapeutic antibiotic use as parity and production level increased, whereas Simmentals showed a more gradual transition. Nevertheless, across all parity and production categories, substantial antibiotic application in uninfected cows persisted regardless of breed. These results, based on a 10-year analysis of test-day records, indicate the need to implement selective dry cow therapy (SDCT), which targets only cows likely to have intramammary infections, on the basis of somatic cell counts and clinical indicators. Two refined datasets were prepared for this purpose, including over 2.5 million test-day records for Holstein cows and more than 2.8 million for Simmental cows. Adjusted antibiotic use according to cow parity, production level and breed could reduce unnecessary antimicrobial treatments without compromising udder health or milk production in subsequent lactations. This approach promotes rational antibiotic use and supports sustainable dairy production in line with EU Regulation 2019/6 and broader efforts to combat antimicrobial resistance (AMR). mastitis antibiotic use somatic cell count (SCC) selective dry cow therapy (SDCT) govedo krave reprodukcija presušitev število somatskih celic antibiotiki cefapirin true false true Angleški jezik Hrvaški jezik Članek v reviji 2026-08-25 09:25:21 2026-08-25 09:25:27 2026-08-26 04:13:04 0000-00-00 00:00:00 2026 0 0 Str. 212-225 [no.] 3 [Vol.] 96 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 636.2 1331-8055 10.24099/vet.arhiv.2995 288739843 RAZ_Ljubojevic_Boris_2026.pdf RAZ_Ljubojevic_Boris_2026.pdf 1 F99670BD47E268F53C1B7196B5E1F6CE 87388ff828e20a7edb55d9a891b85c445cd0275a83a45d155493bd16fec646c9 bf95b890-a055-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=245023 Biotehniška fakulteta 0 0 0