20.500.12556/RUL-185886 Uporaba nanomaterialov MXene na razvijajočih se bioloških in biomedicinskih področjih Nanomaterials MXenes as a Tool in Emerging Biological and Biomedical Technologies V diplomskem delu so predstavljeni obetavni nanomateriali MXene, ki združujejo redke kombinacije lastnosti, kot so električna in kovinska prevodnost ter hidrofilnost in biokompatibilnost. Po strukturi so karbidi, nitridi in karbonitridi prehodnih kovin s splošno formulo Mn+1 Xn Tx , kjer "M" predstavlja kation prehodne kovine, "X" ogljik ali dušik, "T" pa končno površinsko funkcionalno skupino. Fizikalno-kemijske lastnosti MXenov so neposredno povezane z njihovo sintezo, ki jo glede na smer gradnje delimo na tri pristope: "top-down", "up-bottom" ter "bottom-up". Za preučitev in razvoj aplikacij je pomembno poznavanje delovanja materialov na različnih bioloških ravneh. Na molekularni ravni MXeni zaradi svoje visoke specifične površine in Van der Waalsovih sil s proteini tvorijo posebno strukturo – proteinsko korono, prav tako tvorijo interakcije z nukleinskimi kislinami in lipidi. Na celični in tkivni ravni MXeni tvorijo reaktivne kisikove spojine, ki delujejo citotoksično in protibakterijsko. V primerjavi z nanomateriali iz družine grafenov so MXeni manj citotoksični in bolj biokompatibilni, kar jim skupaj z možnostjo površinske funkcionalizacije ter elektro-fototermičnih lastnosti omogoča širši spekter delovanja na različnih področjih. V biomedicini ponujajo možnost uporabe za dostavo zdravil, fototermalno terapijo tumorjev in celjenje kroničnih ran. V bioinženirstvu pa so uporabni kot občutljivi biosenzorji ter komponente v 3D-tisku, biološkem slikanju in ločevalnih membranah. The thesis presents promising MXenes nanomaterials that exhibit a rare synergy of properties, such as electrical and metallic conductivity, hydrophilicity and biocompatibility. Structurally, they are carbides, nitrides and carbonitrides of transition metals, with the general formula Mn+1 Xn Tx, where "M" represents a transition metal cation, "X" carbon or nitrogen, and "T" a final surface functional group. The physicochemical properties of MXenes are directly related to their synthesis, which is divided into three approaches depending on the direction of construction: "top-down", "up-bottom" and "bottom-up". To evaluate and develop potential applications, it is essential to know the functioning of materials at different biological levels. At the molecular level, MXenes, due to their high specific surface area and Van der Waals forces, form a special structure — the protein corona. They also form interactions with nucleic acids and lipids. At the cellular and tissue level, MXenes form reactive oxygen species, which have cytotoxic and antibacterial effects. Compared to graphene-family nanomaterials, they are less cytotoxic and more biocompatible, which, together with the possibility of surface functionalization and electro-photothermal properties, opens a wider spectrum of applications in various fields. In biomedicine, they offer the possibility of use for drug delivery, photothermal therapy of tumors and healing of chronic wounds. In bioengineering, they are used as sensitive biosensors and as components in 3D printing, biological imaging and separation membranes. nanomateriali nanotehnologija 2D materiali MXene biološka reaktivnost nanomaterials nanotechnology 2D materials MXene biological reactivity true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2026-08-22 07:16:05 2026-08-22 07:16:16 2026-08-24 12:55:00 0000-00-00 00:00:00 2026 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 285418 288659715 60425.pdf 60425.pdf 1 C399C2C4CA921AF2A5F08D249F4B67F9 b14665f22e380b61f715b0d5612afd21b1ec3c083f72a41d703353a1b56865ac 351de774-9de8-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=244893 Biotehniška fakulteta 0 0 0