20.500.12556/RUL-185791 Urinary extracellular vesicles toward non-invasive biomarker discovery in kidney graft monitoring Urinary extracellular vesicles (uEVs) have emerged as a promising and versatile source of non-invasive biomarkers for kidney allograft monitoring. This review summarizes current evidence on uEV-derived biomarkers, including proteins, gene expression signatures, microRNAs, and extracellular vesicle-associated DNA, highlighting their potential role in detecting allograft rejection, calcineurin inhibitor nephrotoxicity, and progressive graft dysfunction. Urinary EVs reflect molecular processes occurring within the graft, including immune activation, metabolic dysregulation, and tissue remodelling. Consequently, the analysis of uEVs may offer real-time information on graft status through a readily accessible biological fluid, complementing conventional surveillance strategies and enabling earlier detection of allograft injury. For kidney transplant recipients. The effective uEV translation into clinical practice will require a collective efforts to standardized analytical workflows, validate findings in large prospective multicentric studies, and integrate uEV-based assays into precision medicine approaches. biomarkers exosomes kidney transplanation rejection urinary extracellular vesicles biološki označevalci eksosomi presaditev ledvice zavrnitev urinski zunajcelični vezikli true false true Angleški jezik Slovenski jezik Članek v reviji 2026-08-20 11:21:06 2026-08-20 11:21:12 2026-10-06 16:27:45 0000-00-00 00:00:00 2026 0 0 11 str. iss. 4, art. 101046 Vol. 40 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.6 0955-470X 10.1016/j.trre.2026.101046 287709955 RAZ_Tanzi_Adele_2026.pdf RAZ_Tanzi_Adele_2026.pdf 1 E907E804A8D32A765938D711931031B6 3a2f35ec3ba4ab0ed00cdf8851574a90df7a58d6258b55653605c85371b1e128 7b5c159f-9c78-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=244763 https://www.sciencedirect.com/science/article/pii/S0955470X2600056X?via%3Dihub 1 1a3ab7ea-9c78-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=244762 Medicinska fakulteta 0 0 0