20.500.12556/RUL-185783 Urinary extracellular vesicles a position paper by the urine task force of the international society for extracellular vesicles Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast-growing scientific field. In the last decade urinary extracellular vesicles (uEVs) were shown to mirror molecular pro- cesses as well as physiological and pathological conditions in kidney, urothelial and prostate tissue. Therefore, several methods to isolate and characterize uEVs have been developed. However, methodological aspects of EV separation and analysis, including normalization of results, need further optimization and standardization to foster scientific advances in uEV research and a subsequent successful translation into clinical practice. This position paper is written by the Urine Task Force of the Rigor and Standardization Subcommittee of ISEV consisting of nephrologists, urologists, cardiologists and biologists with active experience in uEV research. Our aim is to present the state of the art and identify challenges and gaps in current uEV-based analyses for clinical applications. Finally, recommendations for improved rigor, reproducibility and interoperability in uEV research are provided in order to facilitate advances in the field. urine prostate bladder urin prostata mehur true false true Angleški jezik Slovenski jezik Članek v reviji 2026-08-20 10:40:00 2026-08-20 10:40:07 2026-08-21 04:30:23 0000-00-00 00:00:00 2021 0 0 39 str. iss. 7, art. e1209 Vol. 10 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 2001-3078 10.1002/jev2.12093 64163331 RAZ_Erdbrugger_Uta_2021.pdf RAZ_Erdbrugger_Uta_2021.pdf 1 85BCE7AFA293FB33A28492A2F84459F8 a6d8e87148e68314a4cdc66e49252c1711d3a78d998a42642bc53b1c7fcf9706 89568910-9c73-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=244746 https://onlinelibrary.wiley.com/doi/epdf/10.1002/jev2.12093 1 5e1a2c4b-9c72-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=244744 Medicinska fakulteta 0 0 0