20.500.12556/RUL-185482 The effect of eggshell hydroxyapatite powder and autologous bone marrow on the healing of bone defects in rabbits Vpliv prahu hidroksiapatita iz jajčne lupine in avtolognega kostnega mozga na celjenje kostnih poškodb pri kuncih The repair of bone defects remains a challenge for clinical orthopedic surgery. Therefore, the present study was designed to evaluate the effect of using eggshell hydroxyapatite (eHA), which was prepared previously from avian eggshell by hydrothermal method and autologous bone marrow aspirated from the femoral bone, on the healing of bone gap defect on the radius bone of the right forelimb in rabbits. This study was conducted on 28 male rabbits divided randomly into four groups each (n=7); in all experimental animals (10 mm length × 2mm width), a bone gap was induced at the mid-shaft of the radius bone reaching the marrow cavity at the right forelimb. The defect in GI was left open as a control group without any additives. In GII, the bone gap was filled with eHA powder; in GIII, it was filled with eHA powder. The bone gap was filled with autologous bone marrow, and in GIV, the bone defect was equally filled with a combination of eHA and bone marrow. Experimental animals were followed up clinically, radiographically at (2, 4, 6, 8) weeks post-operatively, and histopathologically at (4, 6) weeks post-operatively. The radiological and histopathological findings revealed promising results in treated groups compared to a control group, with the best results in the combination of eHA and autologous bone marrow. In conclusion, the use of eHA and autologous bone marrow is considered a beneficial graft material in bone defect regeneration hydroxyapatite avian eggshell powder bone gap true false true Angleški jezik Slovenski jezik Članek v reviji 2026-08-06 13:55:19 2026-08-06 13:55:24 2026-08-07 04:08:24 0000-00-00 00:00:00 2025 0 0 Str. 201-207 iss. 3 Vol. 62 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-01-01 636.09:611 2385-8761 10.26873/SVR-1829-2024 286111747 effect.pdf effect.pdf 1 B014415804E62916CA75F9F454AE8EA8 3992566a233d2c4cfc8f476a860aaf0951b58c75fdfe08b47b5fd45cc17b5526 89519e91-918d-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=244018 https://www.slovetres.si/index.php/SVR/article/view/1829/927 1 5db83800-918d-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=244017 Veterinarska fakulteta Slovenian veterinary research 0 0 0