20.500.12556/RUL-185264 Inflammatory biomarkers as predictors of prognosis in patients after transcatheter aortic valve implantation Background: The expanding role of transcatheter aortic valve implantation (TAVI) highlights the need to identify factors influencing long-term outcomes. Systemic inflammatory response syndrome (SIRS) is a frequent post-procedural event that may adversely affect prognosis. Measurement of inflammatory biomarkers may improve the understanding of underlying mechanisms and refine patient risk stratification. Methods: This single-center, prospective cohort study, enrolled 62 consecutive patients undergoing TAVI, who were followed for up to 5 years. Blood samples were collected before TAVI, at 24 h and 3–6 months post-procedure. Changes in biomarker levels, predictors of SIRS, and inflammatory predictors of long-term outcomes were analyzed. Results: SIRS developed in 45% of patients. Significant temporal changes were observed in hs-CRP, TNF-α, sST2/IL-33, IL-10, and IL-2 levels, irrespective of baseline or procedural characteristics. The development of SIRS was associated with a higher risk of all-cause mortality or unplanned hospitalization at 5 years (HR 3.07, 95% CI 1.57–6.00; p = 0.001). Baseline hs-CRP (HR 1.21, 95% CI 1.09-1.35; p < 0.001) and IFN-γ (HR 1.22; 95% CI 1.09–1.36; p < 0.001) levels were predictive of adverse outcomes. In multivariable Cox analysis, these associations remained, though findings should be interpreted cautiously given the limited sample size. Conclusions: SIRS is a common post-TAVI phenomenon and may be linked to long-term outcomes. Elevated pre-procedural hs-CRP and IFN-γ levels were associated with higher risk for adverse events, suggesting they may serve as exploratory biomarkers for risk stratification in this population. systemic inflammatory response syndrome SIRS transcatheter aortic valve implantation high sensitivity CRP hs-CRP interferon gamma IFN-γ inflammatory biomarkers true false true Angleški jezik Ni določen Izvleček, povzetek 2026-07-30 09:37:01 2026-07-30 09:37:06 2026-07-31 04:12:02 0000-00-00 00:00:00 2026 0 0 11 str. art. 1722293 Vol. 12 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2297-055X 10.3389/fcvm.2025.1722293 266429443 RAZ_Vitez_Luka_2026.pdf RAZ_Vitez_Luka_2026.pdf 1 9AFFF0E2A3B6FEFC5D76008E877049B5 5ee303b118a08d16bcc8d9ad600fe2a20bc3e21f6c1aefb7ce04336025c3cc2b b74385cc-8be9-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=243614 https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1722293/full 0 c57945e1-8be9-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=243615 Medicinska fakulteta 0 0 0