20.500.12556/RUL-185155 Postnatal CMV infection in extremely premature newborns a single-center exploratory study Background/objectives: The impact of postnatal CMV infection in extremely premature newborns is poorly characterized. We aimed to determine the impact and outcomes of postnatal CMV infection in a population of extremely premature newborns of gestational age of less than 29 weeks hospitalized in the Department of Perinatology, Division of Gynecology, University Medical Center Ljubljana. Methods: We included all extremely premature newborns of gestational age of less than 29 weeks treated in the Department of Perinatology between December 2022 and December 2024. Newborns were screened for CMV infection at set timepoints and congenital infection was excluded with PCR testing. Additional PCR testing for CMV was performed if newborns developed clinical features suspect for postnatal CMV infection. Clinical characteristics and treatment outcomes of newborns were noted. Mothers of infected newborns had their CMV serostatus determined. Results: In total, 63 extremely premature newborns were included, and 14 newborns had confirmed postnatal CMV infection. Postnatal CMV infection was associated with hepatosplenomegaly and lower platelet and leukocyte counts compared to controls. We found no association between postnatal CMV infection and other neonatal comorbidities. Conclusions: In our study, postnatal CMV infection was associated with a more severe and prolonged clinical course of extremely premature newborns compared to uninfected controls; however, in multivariable analysis, the association with a prolonged length of stay was no longer statistically significant. The results suggest that preventing postnatal CMV infection in this population is important. breast milk extremely premature newborns leukopenia postnatal CMV thrombocytopenia materino mleko zjemno nedonošeni novorojenčki levkopenija postnatalna okužba s CMV postnatalni citomegalovirus trombocitopenija true false true Angleški jezik Slovenski jezik Članek v reviji 2026-07-25 06:46:50 2026-07-28 11:22:53 2026-07-29 04:03:37 0000-00-00 00:00:00 2026 0 0 13 str. iss. 5, art. 703 Vol. 13 May 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-053.2 2227-9067 10.3390/children13050703 280392451 RAZ_Kosicek_Rok_2026.pdf RAZ_Kosicek_Rok_2026.pdf 1 D48B4E743BF7ABA0DD13EE6648A13E36 d0c468eb03b70c1fd68da46945b24b8a3f56e382791d1a870a16b5748c8d853f 026abd59-8a66-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=243500 https://www.mdpi.com/2227-9067/13/5/703 1 9f9f0a30-87e3-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=243385 Medicinska fakulteta 0 0 0