20.500.12556/RUL-184915 The C Allele of rs2073618 and rs3134069 of the osteoprotegerin gene is associated with diabetic retinopathy in Slovenian patients with type 2 diabetes Background: Osteoprotegerin (OPG) is best known for regulating bone remodeling, vascular calcification, apoptosis, and immune responses. Recent studies also suggest that OPG may play an important role in diabetic microvascular complications such as diabetic retinopathy (DR). Objectives: The aim of our cross-sectional case–control study was to assess the relationship between the OPG variants (rs2073618 and rs3134069) and DR in a large cohort of subjects with type 2 diabetes (T2DM). Methods: A total of 1554 subjects with T2DM were enrolled in this cross-sectional case–control study: 577 with DR and 977 without DR. Genotyping was performed using StepOne Real-Time PCR with TaqMan genotyping assays. Results: Our data indicated that the prevalence of the C minor allele was significantly higher among patients with DR and type 2 diabetes in both polymorphisms. Furthermore, individuals carrying the CC genotype of the rs2073618 had a 1.42-fold increased likelihood of DR, while carriers of the CC or CA genotypes of the rs3134069 exhibited a 1.55-fold higher likelihood of DR. Conclusions: Taken together with existing evidence, these results suggest that OPG polymorphisms may be involved in the development of DR. diabetic retinopathy genetic association study osteoprotegerin genetic polymorphism rs3134069 rs2073618 diabetična retinopatija genetska asociacijska študija osteoprotegerin genetski polimorfizem true false true Angleški jezik Slovenski jezik Članek v reviji 2026-07-17 07:25:35 2026-07-17 07:25:39 2026-07-31 12:24:23 0000-00-00 00:00:00 2026 0 0 10 str. iss. 7, art. 135 Vol. 7 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.379 2673-4540 10.3390/diabetology7070135 285109507 RAZ_Stare_Stella_2026.pdf RAZ_Stare_Stella_2026.pdf 1 12E2322EBBACC7136389C5B0BCEB1769 6be3dbb935759b676754e81ac9fd1030a7ee1b31489fcf2199796e72d6c4383e f57c0017-8730-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=243361 https://www.mdpi.com/2673-4540/7/7/135 1 c0bad61d-819f-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=240312 Medicinska fakulteta 0 0 0