20.500.12556/RUL-184364 Povezava genetskih polimorfizmov v dopaminergični poti s poznimi zapleti pri bolnikih s sladkorno boleznijo tipa 2 Association of genetic polymorphisms in the dopaminergic pathway with late complications in patients with type 2 diabetes Dopaminergični sistem ima pomembno vlogo v patofiziologiji sladkorne bolezni tipa 2 (SB2) in pri razvoju poznih zapletov SB2, saj uravnava fiziološke procese v trebušni slinavki, ledvicah, mrežnici in simpatičnem živčevju. Preučevali smo potencialen vpliv izbranih polimorfizmov v genih COMT, DRD1, DRD2 in DRD3 na razvoj poznih zapletov, ki se pogosto pojavljajo pri bolnikih z neurejeno SB2. V raziskavo smo vključili 344 klinično dobro opredeljenih bolnikov s SB2. Z metodo KASP smo izvedli genotipizacijo ter rezultate statistično analizirali. Statistično značilnih povezav z urejenostjo sladkorne bolezni ali krvnim tlakom nismo potrdili, kar pripisujemo majhnemu vzorcu, vplivu zdravljenja z antihipertenzivi, širšemu genetskemu ozadju in okoljskim dejavnikom. Med poznimi zapleti smo statistično značilno povezavo potrdili le za polimorfizem DRD1 rs4532 in diabetično retinopatijo, kar potrjuje ugotovitve predhodnih raziskav o vplivu sprememb aktivnosti receptorja D1 na patološke spremembe mrežnice. Dopaminergic system has a major role in the pathophysiology of type 2 diabetes mellitus (T2DM) and its associated late complications by regulating physiological processes in the pancreas, kidneys, retina, and the sympathetic nervous system. We investigated the potential influence of selected COMT, DRD1, DRD2 and DRD3 polymorphisms on the development of late complications frequently observed in patients with poorly controlled T2DM. The study included a cohort of 344 clinically well-defined patients with T2DM. After statistical analysis of the results from KASP genotyping, we found no significant associations with glycemic control or blood pressure, which is likely attributable to the size of the cohort, the effects of antihypertensive therapy, as well as the broader genetic and environmental background. The key finding of this study is a statistically significant association between DRD1 rs4532 polymorphism and diabetic retinopathy. This result supports previous findings regarding the impact of altered D1 receptor activity on pathological changes in the retina. No significant associations were found for other complications. sladkorna bolezen tipa 2 pozni zapleti dopaminergična pot COMT dopaminski receptorji type 2 diabetes late complications dopaminergic pathway catechol-O-methyltransferase dopamine receptors true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2026-07-06 09:34:12 2026-07-06 09:34:23 2026-07-31 10:19:34 0000-00-00 00:00:00 2026 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 26087 286554371 Bohorc_Leila_-_Povezava_genetskih_polimorfizmov_v_dopaminergicni_poti_s_poznimi_zapleti_pri_boln.pdf Bohorc_Leila_-_Povezava_genetskih_polimorfizmov_v_dopaminergicni_poti_s_poznimi_zapleti_pri_boln.pdf 1 EF2005C636C7D7AE185D47D44E10072A 507a1d3dafec7671b437ed706f1c32069995c8f9bd469cabd9b163762570a47d ff227abc-790c-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=237047 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0