20.500.12556/RUL-184186 Early atrial ectopic beats and atrial conduction delay predict atrial fibrillation Zgodnji preddvorni ektopični utripi in upočasnjen preddvorni prevod napovedujejo preddvorno fibrilacijo Background: Atrial fibrillation/flutter (AF/AFl) is commonly diagnosed arrhythmia, associated with increased morbidity and mortality. Therefore, we have to improve our early AF/AFl diagnostics. Several studies indicated association between conduction delay, excessive atrial ectopic beats (AEBs) and AF/AFl onset. Association with some other AEB features is less clear. Objective: To validate the role of early AEBs from Holter-ECG in relation to documented AF/AFl events. Methods and Results: We enrolled 14 consecutive patients (6 female, median 60.5 years) with documented AF/AFl during or within 6 months after Holter-ECG (AF-group). Control group consisted of 10 clinically similar consecutive patients (5 female, median 64.5 years), without any evidence of AF/AFl, but with comparable burden of AEBs. Holter-ECGs were examined with 3-channel Holter system (Schiller, Darwin2 software). 24-hour data were analyzed for number and/or burden (%) of: a) AF/AFl, b) AEBs, c) early-AEBs (coupling interval cut-off <530 ms), d) AEB pairs, triplets, runs, and e) bigeminy. In addition, P-wave duration (cut-off <130 ms), PQ, QRS, and QTc were measured. AF-group had higher burden of early-AEBs (p<0.03) and longer P-waves (p<0.05) than controls. In both groups, non-conducted and aberrantly-conducted early-AEBs, AEBs in bigeminy, pairs, triplets and runs were found, as-well-as no difference for PQ, QRS, and QTc (p=NS). The majority of 243 AF/AFl events started during day-time and in 83% with early-AEBs. Before AF onset, outbursts of early-AEBs were encountered in 58% of patients. Izhodišča: Preddvorna fibrilacija/undulacija (AF/AU) je pogosta motnja srčnega ritma, ki je povezana z višjo umrljivostjo in obolevnostjo. Zato jo je treba čim prej diagnosticirati. Rezultati več raziskav kažejo na povezavo med upočasnjenim preddvornim prevodom, velikim številom preddvornih ektopičnih utripov (AES) in pojavom AF/AU. Manj jasna je povezava z nekaterimi drugimi značilnostmi AES. Cilj raziskave: Vrednotiti smo želeli pomen zgodnjih AES pri holterskem elektrokardiogramu (EKG) v povezavi z zabeleže-nimi epizodami AF/AU. Metode in rezultati: V pilotsko raziskavo smo vključili 14 zaporednih bolnikov (6 žensk, mediana starost 60,5 leta) z doku-mentirano AF/AU v zapisu holterskega EKG ali do 6 mesecev po njem (skupina z AF/AU). V kontrolni skupini je bilo 10 zapo-rednih bolnikov s podobno klinično sliko (5 žensk, mediana starost 64,5 leat) brez AF/AU v anamnezi, vendar s podobnim bremenom AES. Holterski EKG smo beležili s 3-kanalnim sistemom (Schiller, Darwin2 software). V 24-urnih zapisih EKG smo analizirali število in/ali breme (%) naslednjih parametrov: a) AF/AU, b) AES, c) zgodnjih AES (vezni interval < 530 ms), d) AES v parih, tripletih in salvah in e) prisotnost bigeminije; poleg tega pa še trajanje vala P (normalna vrednost < 130 ms), PQ, QRS in QTc. Skupina z AF/AU je imela večje breme zgodnjih AES (p< 0,03) in daljši val P (p< 0,05) kot kontrolna skupina. V obeh skupinah smo zabeležili neprevedene in aberantno prevedene AES, AES v bigeminiji, parih, tripletih in salvah. Prav tako ni bilo razlike v trajanju PQ, QRS in QTc (p=NS). Večina od 243 primerov AF/AU se je sprožila v dnevnem času, v 83 % z zgodnjo AES. Pri 58 % smo zabeležili pred pojavom AF/AU porast števila zgodnjih AES.Zaključek: Večje breme zgodnjih AES v holterskem EKG in daljše trajanje vala P napovedujejo pojav AF/AU. atrijska fibrilacija motnje srčnega ritma preddvorni ektopični utripi elektrokardiogram holtersko monitoriranje atrial fibrillation atrial ectopic beats electrocardiogram holter-monitoring true false true Angleški jezik Slovenski jezik Članek v reviji 2026-07-01 11:16:02 2026-07-01 11:16:03 2026-10-08 10:31:00 0000-00-00 00:00:00 2025 0 0 Str. 3–15 št. 1/2 Letn. 94 jan./feb. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.12-008.313 1318-0347 10.6016/ZdravVestn.3532 227806723 RAZ_Sinkovec_Matjaz_2025.pdf RAZ_Sinkovec_Matjaz_2025.pdf 1 6EB54A1E78C11BBFA8BBF5EB60A0D524 724eb8beee79c67670fa55aad6f4e95ad46061bad56a33f4e9c0d4b4e22565da 8e194d1c-752d-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=236764 https://vestnik.szd.si/index.php/ZdravVest/article/view/3532 1 63ee0fe2-752d-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=236763 Medicinska fakulteta 0 0 0