20.500.12556/RUL-183978 Curing the brain in search for new astrocyte-specific therapies Astroglia, an extended class of homeostatic and defensive cells of the central nervous system (CNS), contribute to the pathogenesis of all known neurological and neuropsychiatric disorders. The pathophysiology of astrocytes is complex, mutable, disease and disease-stage specific. In neuroinflammatory lesions and in various chronic conditions, astrocytes undergo an evolutionary conserved defensive remodeling known as reactive astrogliosis, which produces highly heterogeneous reactive astrocytic phenotypes. Broadly, reactive astrogliosis can be classified into proliferative anysomorphic barrier-forming astrogliosis characteristic of traumatic CNS lesions and nonproliferative isomorphic gliosis widely manifested in chronic neuropathologies. In addition, in many pathologies, astrocytes undergo atrophy and asthenia with resulting loss of homeostatic support and neuroprotection precipitating neuronal damage. Reactive and atrophic astrocytes may coexist or emerge in sequence in a disease-stage-dependent manner. Several classes of astrocyte-specific molecules and processes implicated in various diseases of the CNS represent therapeutic targets. Astrocyte-specific therapeutic strategies may improve both disease-preventing and disease-modifying therapeutic outcomes. brain astrocytes gliosis možgani atrosciti glioza true false true Angleški jezik Slovenski jezik Članek v reviji 2026-06-23 10:27:23 2026-06-23 10:27:27 2026-07-07 10:17:04 0000-00-00 00:00:00 2026 0 0 Str. 1086-1127 no. 4 Vol. 58 Apr. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 2092-6413 10.1038/s12276-026-01712-4 282363395 RAZ_Verkhratsky_Alexei_2026.pdf RAZ_Verkhratsky_Alexei_2026.pdf 1 480947CF71161FED08DF10B5B467C347 5a335fc626e208f13edc02882a306fc299dfa0cfe5682485cde501dcdb0cc6a8 64a09f32-6edd-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=236327 https://www.nature.com/articles/s12276-026-01712-4 1 4c6c9c15-6edd-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=236326 Medicinska fakulteta 0 0 0