20.500.12556/RUL-183766 Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer’s disease neuropathology Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer’s disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally at threonine-212, but the contribution of p-tau212 alone to AD is unknown. We developed a blood-based immunoassay that is specific to p-tau212 without cross-reactivity to p-tau217. Here, we examined the diagnostic utility of plasma p-tau212. In five cohorts (n = 388 participants), plasma p-tau212 showed high performances for AD diagnosis and for the detection of both amyloid and tau pathology, including at autopsy as well as in memory clinic populations. The diagnostic accuracy and fold changes of plasma p-tau212 were similar to those for p-tau217 but higher than p-tau181 and p-tau231. Immunofluorescent staining of brain tissue slices showed prominent p-tau212 reactivity in neurofibrillary tangles that co-localized with p-tau217 and p-tau202/205. These findings support plasma p-tau212 as a peripherally accessible biomarker of AD pathophysiology. plasma p-tau212 diagnostics Alzheimer disease neuropathology plazma p-tau212 diagnostika Alzheimerjeva bolezen nevropatologija true false true Angleški jezik Slovenski jezik Članek v reviji 2026-06-18 09:06:27 2026-06-18 09:06:32 2026-08-11 08:20:30 0000-00-00 00:00:00 2024 0 0 16 str. art. 2615 Vol. 15 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 2041-1723 10.1038/s41467-024-46876-7 192269315 RAZ_Kac_Przemyslaw_R._2024.pdf RAZ_Kac_Przemyslaw_R._2024.pdf 1 E900D689A16F0E2A911E05E5E3120E3F fee21166d457c1defecd4bf8f6c7ad9b52f4166f19afd59573cfe2072cfb4dee 32c8223d-6ae4-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=235923 https://www.nature.com/articles/s41467-024-46876-7 0 fe8a9bdf-6ae5-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=235924 Medicinska fakulteta Fakulteta za farmacijo 0 0 0