20.500.12556/RUL-183669 Vzpostavitev sistema za razvrščanje kemikalij in pripravo ocen tveganja v Lekarni Univerzitetnega kliničnega centra Ljubljana Development of a system for chemical classification and risk assessment in the Pharmacy of the University medical centre Ljubljana Uredba REACH (Uredba (ES) št. 1907/2006) je temeljni pravni akt EU na področju kemikalij, katerega namen je zaščita zdravja ljudi in okolja. Vključuje registracijo, evalvacijo, avtorizacijo in omejitve za proizvodnjo, dajanje v promet in uporabo kemikalij. Uredbo REACH dopolnjuje uredba CLP (Uredba (ES) št. 1272/2008), ki določa enoten sistem razvrščanja, označevanja in pakiranja kemikalij v EU, vključno z uporabo piktogramov, opozorilnih besed, stavkov o nevarnosti in previdnostnih stavkov. V Sloveniji je izvajanje uredbe CLP dodatno urejeno z Uredbo o izvajanju Uredbe (ES) št. 1272/2008, katere namen je zagotoviti prenos evropskih določb uredbe CLP v slovenski pravni red in omogočiti njihovo učinkovito izvajanje na nacionalni ravni, promet s kemikalijami pa je v Sloveniji urejen z Zakonom o kemikalijah. Nevarne kemikalije so po uredbi CLP razvrščene na kemikalije, ki imajo nevarne fizikalne lastnosti, kemikalije, ki imajo nevarne lastnosti za zdravje, in kemikalije, ki imajo nevarne lastnosti za okolje. Skladno z zakonodajo je delodajalec za varno delo z nevarnimi kemikalijami primoran pripraviti oceno tveganja za varno delo z nevarnimi kemikalijami, katere namen je prepoznati tveganja ter jih zmanjšati ali odpraviti. V raziskovalnem delu magistrskega dela smo uporabili metodo sistematičnega pregleda kemikalij. Z namenom razvrstitve vseh kemikalij, ki jih uporabljajo v Lekarni Univerzitetnega kliničnega centra Ljubljana, smo tem sprva opredelili nevarnosti, nato pa jih razvrstili v razrede nevarnosti. Skupno smo med 244 obravnavanimi kemikalijami 133 kemikalij (55 %) razvrstili med nevarne kemikalije. Razvrščanje kemikalij v posamezne razrede smo izvedli skladno z uredbo CLP. Po izvedenem razvrščanju kemikalij smo izvedli tudi primer ocene tveganja za izbrano kemikalijo, skladno z navodili, ki smo jih pripravili v okviru magistrske naloge. Največji delež (97 %) obravnavanih kemikalij ima nevarne lastnosti za zdravje. Več kot tretjina kemikalij pa spada v več razredov nevarnosti hkrati, kar potrjuje, da je ocenjevanje nevarnosti kemikalij kompleksen proces, saj posamezne snovi pogosto predstavljajo kombinirana tveganja. The REACH Regulation (Regulation (EC) No 1907/2006) is the EU’s fundamental legal framework for chemicals, designed to protect human health and the environment. It covers the registration, evaluation, authorization, and restrictions for the production, placement on the market, and use of chemicals. The REACH Regulation is complemented by the CLP Regulation (Regulation (EC) No. 1272/2008), which establishes a harmonized system for the classification, labelling, and packaging of chemicals in the EU, including the use of pictograms, signal words, hazard statements, and precautionary statements. In Slovenia, the implementation of the CLP Regulation is further regulated by the Regulation on the Implementation of Regulation (EC) No. 1272/2008, the purpose of which is to ensure the incorporation of the European requirements of the CLP Regulation into Slovenian law and to enable their effective implementation at the national level; while the trade in chemicals in Slovenia is regulated by the Law on Chemicals. According to the CLP Regulation, hazardous chemicals are classified into chemicals with hazardous physical properties, chemicals with hazardous health properties, and chemicals with hazardous environmental properties. In accordance with the law, an employer is required to prepare a risk assessment for the safe handling of hazardous chemicals, the purpose of which is to identify risks and reduce or eliminate them. In the research section of this master’s thesis, we employed a systematic review of chemicals. To classify all chemicals used at the University medical centre Ljubljana Pharmacy, we first identified their hazards and then classified them into hazard categories. Of the 244 chemicals reviewed, a total of 133 (55 %) were classified as hazardous chemicals. The classification of chemicals into individual categories was performed in accordance with the CLP Regulation. After classifying the chemicals, we also performed a risk assessment for a selected chemical, in accordance with the guidelines we prepared as part of the master’s thesis. The majority (97 %) of the chemicals examined possess hazardous properties for human health. However, more than a third of the chemicals fall into multiple hazard classes simultaneously, confirming that chemical hazard assessment is a complex process, as individual substances often present combined risks. kemikalije uredba REACH uredba CLP ocena tveganja chemicals REACH Regulation CLP Regulation risk assessment true false false [Ž. Šebenik] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2026-06-17 08:46:18 2026-06-17 08:46:29 2026-06-19 11:44:36 0000-00-00 00:00:00 2026 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1970-01-01 615.1:614.8:54(043.2) 125514 282169091 32191.pdf 32191.pdf 1 98B92752E54AE298D4182EB922847801 58a624704070f88176f12541eed9c4807022e4055d24a868329f7e817b912dd1 354dc9b3-6a18-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=235792 Fakulteta za farmacijo 0 0 0