20.500.12556/RUL-183644 Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins Tick-borne encephalitis virus (TBEV) vaccine breakthrough (VBT) infections are not uncommon in endemic areas. The clinical and immunological outcomes have been poorly investigated. We assessed the magnitude and specificity of virus-specific antibody and T cell responses after TBE in previously vaccinated subjects and compared the results with those of unvaccinated TBE patients and study subjects that received vaccination without VBT infection. Symptomatic TBEV infection of unvaccinated study subjects induced virus-specific antibody responses to the E protein and non-structural protein 1 (NS1) as well as T cell responses to structural and other non-structural (NS) proteins. After VBT infections, significantly impaired NS1-specific antibody responses were observed, while the virus-specific T cell responses to the NS proteins were relatively strong. VBT infection caused predominantly moderate to severe disease during hospitalization. The level of TBEV EDIII- and NS1-specific antibodies in unvaccinated convalescent patients inversely correlated with TBE severity and neurological symptoms early after infection. tick-borne encephalitis vaccine T-cells klopni encefalitis cepivo T celice true false true Angleški jezik Slovenski jezik Članek v reviji 2026-06-17 06:53:20 2026-06-18 06:45:52 2026-08-11 08:22:53 0000-00-00 00:00:00 2024 0 0 9 str. art. 141 Vol. 9 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 2059-0105 10.1038/s41541-024-00936-7 203877635 RAZ_Aregay_Amare_2024.pdf RAZ_Aregay_Amare_2024.pdf 1 391ED4896197C7C5F37FA9F9CEC93C30 5dcf945066b5fb3f3a1e9591dc241cbb187a94a4c4aeb9ce22d2f2e2ff822e42 5098a799-6ad3-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=235892 https://www.nature.com/articles/s41541-024-00936-7#Fun 1 684ab7b3-6a08-11f1-9b0d-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=235767 Medicinska fakulteta 0 0 0