20.500.12556/RUL-182505 Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases Non-communicable chronic diseases (NCDs) are most commonly characterized by age-related loss of homeostasis and/or by cumulative exposures to environmental factors, which lead to low-grade sustained generation of reactive oxygen species (ROS), chronic inflammation and metabolic imbalance. Nuclear factor erythroid 2-like 2 (NRF2) is a basic leucine-zipper transcription factor that regulates the cellular redox homeostasis. NRF2 controls the expression of more than 250 human genes that share in their regulatory regions a cis-acting enhancer termed the antioxidant response element (ARE). The products of these genes participate in numerous functions including biotransformation and redox homeostasis, lipid and iron metabolism, inflammation, proteostasis, as well as mitochondrial dynamics and energetics. Thus, it is possible that a single pharmacological NRF2 modulator might mitigate the effect of the main hallmarks of NCDs, including oxidative, proteostatic, inflammatory and/or metabolic stress. Research on model organisms has provided tremendous knowledge of the molecular mechanisms by which NRF2 affects NCDs pathogenesis. This review is a comprehensive summary of the most commonly used model organisms of NCDs in which NRF2 has been genetically or pharmacologically modulated, paving the way for drug development to combat NCDs. We discuss the validity and use of these models and identify future challenges. inflammation model organisms NRF2 non-communicable chronic diseases oxidative stress vnetje modelni organizmi nenalezljive kronične bolezni oksidativni stres true false true Angleški jezik Slovenski jezik Članek v reviji 2026-05-14 10:02:15 2026-05-14 10:02:22 2026-05-27 04:39:57 0000-00-00 00:00:00 2025 0 0 V datoteki je poleg objavljenega članka shranjen tudi njegov popravek, ki je bil objavljen v Redox Biology, vol. 80, 2025, art. 103496, DOI: 10.1016/j.redox.2025.103496 (https://doi.org/10.1016/j.redox.2025.103496). (Datum opombe: 26. 5. 2026) 49 str. art. 103464 Vol. 79 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-092 2213-2317 10.1016/j.redox.2024.103464 228232707 1-s2.0-S2213231724004427-mainext.pdf 1-s2.0-S2213231724004427-mainext.pdf 1 A9F84C41CFB4418102320BB806AAF29B 7e3e15bf7a7d6083f12b7fd045f8cb825a4e0dbe62070ddfd6b0a9e9dfab5af6 42f76c20-58f4-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=234500 https://www.sciencedirect.com/science/article/pii/S2213231724004427 0 ef612e28-4f6a-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=233832 Medicinska fakulteta Zdravstvena fakulteta 0 0 0