20.500.12556/RUL-182413 Differential effects of amphetamine on ultrasonic vocalizations and locomotor activity in a rat model of endogenous depression research data underlying the article The Wistar-Kyoto rat strain (WKY) is a model for treatment-resistant depression, exhibiting behaviors indicative of anhedonia. Although anhedonia is measured using the sucrose preference test (SPT), 50-kHz ultrasonic vocalizations (USVs) hold promise as a complementary assessment tool. This study aimed to detect whether 50-kHz USVs differ in the WKY rats compared to control Wistar (W) rats. First, WKY and W rats were compared for their basal 50-kHz calls. Then, rats were repeatedly treated with four administrations of either amphetamine (AMPH) or morphine (MORPH), and 50-kHz calls were recorded. In addition, the drug-evoked locomotor activity, sucrose consumption in the SPT, and the time spent in the drug- vs. saline-paired compartment in the conditioned place preference (CPP) test were collected. WKY rats emitted fewer basal calls and fewer calls following the first and the fourth AMPH administration. Contrary to controls, AMPH did not affect the number of calls in WKY rats following the first administration. WKY also displayed reduced AMPH-induced locomotor activity and sucrose consumption in the SPT. MORPH did not affect USVs or locomotion in either strain. The results highlight the benefits of 50-kHz calls as a complementary behavioral marker for assessing anhedonia in preclinical models of depression. Wistar-Kyoto rat depression ultrasonic vocalizations anhedonia amphetamine morphine Wistar-Kyoto podgane depresija ultrazvočne vokalizacije anhedonija amfetamin morfin true false false Angleški jezik Slovenski jezik Neznano 2026-05-11 10:06:55 2026-05-18 15:04:03 2026-05-20 04:45:50 0000-00-00 00:00:00 2026 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 README.txt README.txt README 1 F9B3CB8D3C02B07464E98908C595E412 1a5cd7e6a4c660fa148ca108156b60c9e359389b99c5f6aae75eb4ff450e6282 2e4af122-538a-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=234065 USVs.xlsx USVs.xlsx USVs 1 61B1DC596AEEB18070B3BA2BDBE5658D 53d4d57522fc019be03ad2a2862e62e6c4b3098fef3417cb1fe2ed08ee4005e6 5a5d848d-538a-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=234066 SPT_rez.xlsx SPT_rez.xlsx SPT rez 1 D751A9022A1D1AB28EC59A1199BE8635 b8b4b63f8c9f980ba98264de0d6f872d2ac4af7adb38c9dfe8954f1760833db1 709a930f-538a-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=234067 USVs_2024_LOCOMOTION_last10min1.xlsx USVs_2024_LOCOMOTION_last10min1.xlsx USVs 2024 LOCOMOTION last10min 1 298C261EEDEADF15FAD41F1E4209D70B 23fbca7a5ea3423246ed32250b3cdedd6da07f7e5d28ffe918a8aaa2f91150ad 89108800-538a-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=234068 Statistics-USVs_2024_CPP_TEST_FINAL.xlsx Statistics-USVs_2024_CPP_TEST_FINAL.xlsx Statistics-USVs_2024_CPP_TEST_FINAL 1 D636C803B370B3368F9601214CDA854B 2bc81e9303bc44f2dd04bbebdd3867b0b4f2fcdaeb6979b454fc049fdc47ad49 6672d543-4d10-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=233650 Medicinska fakulteta Meritve in testi 0 0 0