20.500.12556/RUL-182330 Nocturnal pulse oxygen saturation dynamics at simulated high altitude predictive value for acute mountain sickness in healthy men born pre-term The physiological sequelae of pre-term birth might influence the responses of this population to hypoxia. Moreover, identifying variables associated with development of acute mountain sickness (AMS) remains a key practically significant area of altitude research. We investigated the effects of pre-term birth on nocturnal oxygen saturation (S$_p$o$_2$) dynamics and assessed the predictive potential of nocturnal S$_p$o$_2$-related metrics for morning AMS in 12 healthy adults with gestational age < 32 weeks (pre-term) and 12 term-born control participants. Participants spent one night at a simulated altitude of ∼4200 m (normobaric hypoxia; fraction of inspired O$_2$= 0.141), with nocturnal S$_p$o$_2$ and heart rate recorded continuously at the fingertip using pulse oximetry and with morning AMS assessed using the Lake Louise scale. Pre-term and term-born participants had similar nocturnal mean S$_p$o$_2$ (mean ± SD; 77% ± 3% vs. 77% ± 4%; P = 0.661), minimum S$_p$o$_2$ (median[IQR]; 67[4]% vs. 69[5]%; P = 0.223), relative time spent with S$_p$o$_2$ < 80% (72% ± 29% vs. 70% ± 27%; P = 0.879) and mean heart rate (79 ± 12 vs. 71 ± 7 beats/min; P = 0.053). However, the increase in S$_p$o$_2$ between the two halves of the night was blunted with prematurity (−0.12% ± 1.51% vs. 1.11% ± 0.78%; P = 0.021). Moreover, the cumulative relative desaturation-based hypoxic ‘load’ was higher with prematurity (32[26]%min/h vs. 7[25]%min/h; P = 0.039), underpinned by increased desaturation frequency (69[49] vs. 21[35] counts/h; P = 0.009). Mean S$_p$o$_2$ , minimum S$_p$o$_2$ , morning S$_p$o$_2$ and relative time spent with S$_p$o$_2$ < 80% predicted AMS incidence better than a random classifier exclusively in the pre-term group, with no other variables predictive of AMS in the two groups separately or combined. Overall, pre-term birth might alter nocturnal S$_p$o$_2$ dynamics and influence AMS prediction in severe hypoxia. sport hypoxia prematurity pulse oximetry sleep šport hipoksija nedonošenost prezgodaj rojeni otroci pulzna oksimetrija spanje true false true Angleški jezik Slovenski jezik Članek v reviji 2026-05-07 11:53:57 2026-05-07 11:53:58 2026-05-08 12:53:14 0000-00-00 00:00:00 2025 0 0 821-831 iss. 6 Vol. 110 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 796:616.12-008.44 1469-445X 10.1113/EP092418 223176963 Experimental_Physiology_-_2025_-_Narang_-_Nocturnal_pulse_oxygen_saturation_dynamics_at_simulated_high_altitude__Predictive.pdf Experimental_Physiology_-_2025_-_Narang_-_Nocturnal_pulse_oxygen_saturation_dynamics_at_simulated_high_altitude__Predictive.pdf 1 7A1304CCC1A31B4A7571690E1C978E9D 8dba5d7cd0edf938c73cc26d78722ce2b103f4bf8753ac5eaa99aeeb8e76c382 2e655d88-4a01-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=233495 https://physoc.onlinelibrary.wiley.com/doi/10.1113/EP092418 Dostop z geslom 1 60c329f5-49fa-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=233489 Fakulteta za šport 0 0 0