20.500.12556/RUL-182309 EULAR study group on 'MHC-I-opathy' identifying disease-overarching mechanisms across disciplines and borders The 'MHC-I (major histocompatibility complex class I)-opathy' concept describes a family of inflammatory conditions with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. Classical MHC-I-opathies such as spondyloarthritis, Behçet's disease, psoriasis and birdshot uveitis are widely recognised for their strong association with certain MHC-I alleles and gene variants of the antigen processing aminopeptidases ERAP1 and ERAP2 that implicates altered MHC-I peptide presentation to CD8$^{+}$ T cells in the pathogenesis. Progress in understanding the cause and treatment of these disorders is hampered by patient phenotypic heterogeneity and lack of systematic investigation of the MHC-I pathway. Here, we discuss new insights into the biology of MHC-I-opathies that strongly advocate for disease-overarching and integrated molecular and clinical investigation to decipher underlying disease mechanisms. Because this requires transformative multidisciplinary collaboration, we introduce the EULAR study group on MHC-I-opathies to unite clinical expertise in rheumatology, dermatology and ophthalmology, with fundamental and translational researchers from multiple disciplines such as immunology, genomics and proteomics, alongside patient partners. We prioritise standardisation of disease phenotypes and scientific nomenclature and propose interdisciplinary genetic and translational studies to exploit emerging therapeutic strategies to understand MHC-I-mediated disease mechanisms. These collaborative efforts are required to address outstanding questions in the etiopathogenesis of MHC-I-opathies towards improving patient treatment and prognostication. psoriatic arthritis Behçet syndrome immune system diseases ankylosing spondylitis psoriatični artritis Behçetov sindrom bolezni imunskega sistema ankilozirajoči spondilitis true false true Angleški jezik Slovenski jezik Članek v reviji 2026-05-07 05:15:54 2026-05-07 08:15:21 2026-10-07 12:10:58 0000-00-00 00:00:00 2023 0 0 Str. 887-896 iss. 7 Vol. 82 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-002 0003-4967 10.1136/ard-2022-222852 275985411 RAZ_Kuiper_Jonas_Jan_Willem_2023.pdf RAZ_Kuiper_Jonas_Jan_Willem_2023.pdf 1 75B538544B87423EF79E1F3C4B6B5998 dd2389e0645ece55a879708c62e353027204f36a5c5f7e3167b853390b80fd39 a3095c14-49dc-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=233458 https://ard.eular.org/article/S0003-4967(24)00398-4/fulltext 1 c6434e2c-49c2-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=233452 Medicinska fakulteta 0 0 0