20.500.12556/RUL-182244 Towards greener-by-design fine chemicals Synthetic frontiers In the face of intensifying market needs and mounting environmental pressures, the pharmaceutical and agrochemical sectors must revisit core aspects of process design. This review proposes a forward-looking framework for “greener-by-design” manufacturing, emphasizing the integration of sustainability from the earliest stages of synthetic planning through to industrial implementation. We focus on four interdependent levers that collectively enable this transformation: (i) solvent choice, with an emphasis on minimization, substitution, or complete elimination; (ii) substrate sourcing, favoring renewable and biomass-derived feedstocks to reduce fossil dependency; (iii) catalyst development, exploring the use of base metals, novel heterogeneous systems, and biocatalysts; and (iv) continuous-flow processing, which enhances safety, scalability, and process control. These strategies are not meant to be applied in isolation but rather in a synergistic, end-to-end manner that accounts for the full lifecycle of chemical products. By aligning synthetic efficiency with environmental responsibility, this review outlines a practical and actionable roadmap for the sustainable production of high-value fine chemicals. The convergence of synthetic chemistry with process engineering, data science, and life cycle thinking will be critical to realizing this vision, ultimately enabling more robust, circular, and future-proof manufacturing paradigms. process design catalysis biocatalysis sustainable production fine chemicals načrtovanje procesov kataliza biokataliza trajnostna proizvodnja fine kemikalije true false true Angleški jezik Slovenski jezik Članek v reviji 2026-05-05 09:22:33 2026-05-05 09:22:33 2026-05-06 04:29:06 0000-00-00 00:00:00 2026 0 0 Str. 619-674 iss. 2 Vol. 55 25 Jan. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 66.011.097 1460-4744 10.1039/d5cs00929d 257931779 RAZ_Gazis_Theodore_A._2026.pdf RAZ_Gazis_Theodore_A._2026.pdf 1 F4C8A4E988AEB3FEF1E9FB645C0D3CB0 8e55495131650b94ef1bd76b1d5e94013284d8e30de5bf871644e88d8952be4f 8a7f382b-4853-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=233321 https://pubs.rsc.org/en/content/articlelanding/2025/cs/d5cs00929d 1 e9104884-4852-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=233318 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0