20.500.12556/RUL-182203 Transferability of patient selection model for proton radiation therapy to lower-income European countries Objectives: Proton therapy is an alternative treatment to photon therapy in head and neck cancer. The Normal Tissue Complication Probability (NTCP) model assists in the patient selection process. This study explores how health technology assessment (HTA) recommendations in lower-income European countries (LIECs) in head and neck cancer can be supported by transferring the NTCP model. Methods: Through 2 workshops in November 2022 and May 2023, the scope of transferability recommendations was established for the head and neck cancer case study of the HTx project. HTA experts from LIECs and HTx consortium rep- resentatives reviewed draft recommendations at a final transferability workshop in November 2023. Experts anonymously voted on the main challenges of transferring the NTCP model to LIECs and ranked these by importance. Finally, an open discussion took place about potential solutions for overcoming the main challenges. Results: Main challenges of transferring the NTCP model to LIECs include lack of available local data, differences in patient pathways, and shortage of HTA experts. Workshop participants agreed that the NTCP model is an improvement to current standard HTA methods. Multiple key recommendations were formed, including that dissemination of real-world data and real-world evidence should be gold standard, coupled with a wide collaboration across stakeholders, and that consideration of transferability aspects could help LIECs when adapting novel methods. Conclusions: According to a multinational panel of experts, the NTCP model is an improvement over current HTA methods. To overcome challenges of its adoption in LIECs, 5 key recommendations were formulated. Central and Eastern Europe health care costs economic aspect central and Eastern European countries head and neck cancer health technology assessment normal tissue complication probability model transferability srednja in vzhodna Evropa zdravstveno varstvo stroški ekonomski vidik true false true Angleški jezik Slovenski jezik Članek v reviji 2026-04-30 11:50:06 2026-04-30 11:53:32 2026-05-01 04:26:53 0000-00-00 00:00:00 2026 0 0 [in press] 2026 0000-00-00 Zaloznikova VTisku NiDoloceno 0000-00-00 0000-00-00 0000-00-00 614.2 2212-1102 10.1016/j.vhri.2026.101628 276721923 1-s2.0-S2212109926000439-main.pdf 1-s2.0-S2212109926000439-main.pdf 1 CB93E018752D5035C75A561DA5FB523E da3b414c60c32c425d84d441c6b44ee288bc877f208da82c84b3a3755c3eb092 085e681e-447a-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=233210 https://www.sciencedirect.com/science/article/pii/S2212109926000439 0 fe7cc1dd-4479-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=233209 Ekonomska fakulteta 0 0 0