20.500.12556/RUL-181881 Effectiveness of voluntary isocapnic hyperpnoea for mitigating hypoxemia and acute mountain sickness in normobaric hypoxia a randomized crossover pilot trial This study aimed to examine the physiological mechanisms associated with Voluntary Isocapnic Hyperpnoea (VIH) in severe hypoxia and evaluated whether such respiratory modulation may attenuate hypoxemia and Acute Mountain Sickness (AMS). Eighteen healthy participants (8 females) completed two 2-hour sessions in a normobaric hypoxic chamber simulating 4200 m above sea level, in randomized order: an experimental session including a 5-minute VIH intervention after 1 h, and a control session without VIH. AMS symptoms, arterial oxygen saturation (SpO$_₂$), heart rate, blood pressure and gases were monitored before and during the hypoxic exposure. Separate repeated- measures ANOVAs were employed to analyze the effects of VIH and differences between the sessions. VIH decreased clinical hypoxemia (from 83.3% to 22.2%) and reduced AMS incidence (from 11.1% to 5.5%). This was associated with an increase in SpO$_₂$ (p = 0.011, ηp$^2$ = 0.341, ω$^2$ = 0.159) and blood oxygen partial pressure (p = 0.027, ηp$^2$ = 0.271, ω$^2$ = 0.112). SpO$_₂$ kinetics differed between sessions (p = 0.011, ηp$^2$ = 0.132, ω$^2$ = 0.061), with higher values during the experimental session. This benefit was acute as differences in SpO$_₂$ were not noted at the final timepoint. Substantial intra-individual variability and no sex-related interactions were observed. These preliminary findings suggest that VIH is a feasible method for transiently improving blood oxygen saturation under hypoxia, and has the potential to attenuate AMS. Further research is nevertheless warranted to clarify the role of VIH within the framework of altitude medicine and address potential mechanistic explanations. Methodological insights from the present study should inform future investigations. sport respiration altitude hypoxia hypoxemia AMS prevention šport dihanje nadmorska višina hipoksija hipoksemija AMS preprečevanje true false true Angleški jezik Slovenski jezik Članek v reviji 2026-04-17 12:42:32 2026-04-17 12:42:33 2026-04-18 04:56:10 0000-00-00 00:00:00 2026 0 0 9 str. art. 4784 Vol. 16 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 796.01 2045-2322 10.1038/s41598-026-35131-2 264718339 s41598-026-35131-2.pdf s41598-026-35131-2.pdf 1 46A20A2EE35A4F2FE7A31E0C67063AAD 37dba92d963009d7642f0f4bb4e6ca4dc4c7f17db8cfe3a08806eedd8403c321 b66672be-3a4a-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=232659 https://www.nature.com/articles/s41598-026-35131-2 1 eafcc9a4-3a49-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=232657 Fakulteta za šport 0 0 0