20.500.12556/RUL-181749 Prevalence of cachexia and outcomes in patients with chronic diseases a national database analysis of 5 484 103 hospitalisations Background: Cachexia is a frequent companion of chronic diseases and a well-established predictor of poor patient perfor- mance and outcome. Since cachexia as a discharge diagnosis is not much investigated, we aimed to investigate prevalence of cachexia in hospitalised patients and their outcome. Methods: We conducted a retrospective analysis of the National Hospital Health Care Statistics Database using the 10th revision of the International Classification of Diseases codes. During period 2004–2019, patients with cachexia were identified, as well as patients with cancer, heart failure, chronic obstructive pulmonary disease and chronic kidney disease. The primary endpoint was the discharge code of cachexia; secondary endpoints were length of hospital stay, in-hospital and post discharge all-cause mortality. Results: In period 2004–2019, 5 484 103 hospitalisations were screened; cachexia was coded 19 348 times (0.35%) in 14 089 pa- tients (67 ± 13 years, 42% women). From 2004 to 2019, prevalence of cachexia increased steadily from 1.2% to 1.9%, which was most prominent for cancer and chronic obstructive pulmonary disease. At one year post discharge, 49% patients with cachexia were dead as compared to 26% in patients without cachexia. In Cox multivariate analysis, cachexia predicted post- discharge death in any of chronic diseases (hazard ratio of 1.28 in heart failure to 1.47 in chronic kidney disease). Conclusions: In our report from a National Hospital Health Care Statistics Database, we found that cachexia was underreported as ICD-10 coded discharge diagnosis in patients with chronic diseases. When diagnosed, it was associated with higher hazard of post discharge mortality. cachexia cancer chronic kidney disease chronic obstructive pulmonary disease heart failure mortality rak kronične ledvične bolezni KOPB srčno popuščanje umrljivost true false true Angleški jezik Slovenski jezik Članek v reviji 2026-04-15 09:22:20 2026-04-15 09:22:27 2026-06-18 09:56:55 0000-00-00 00:00:00 2025 0 0 8 str. iss. 1 Vol. 16 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 614 2190-6009 10.1002/jcsm.13688 225289987 RAZ_Lainscak_Mitja_2025.pdf RAZ_Lainscak_Mitja_2025.pdf 1 D2AC9FDC0E0F9EDE12C30DD68E9576F4 31915de33ad2522608c884b85fc1ba3194299c63422acff762865d5003c7706a 41c48941-389c-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=232458 https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcsm.13688 1 a2f863a1-389b-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=232455 Medicinska fakulteta 0 0 0