20.500.12556/RUL-181690 Critical uncertainties in preclinical research navigating trust, technology, and ethics Animal use in preclinical research is facing growing scientific, ethical and political scrutiny in Europe. Researchers are increasingly required to justify in vivo studies and are urged to replace them with New Approach Methodologies (NAMs), even where these are not yet fit for purpose. In response to this pressure, members of the COST Action CA20135 “Improving biomedical research by automated behaviour monitoring in the animal home-cage” (TEATIME) held a Strategic Foresight Workshop in March 2025 to examine the future of animal research in Europe. The resulting scenarios reveal risks of over-regulation, outsourcing animal experiments to countries with weaker standards, and erosion of research quality, but also highlight opportunities to combine validated NAMs with high-quality in vivo work under robust ethical oversight. This short communication summarises the workshop's main insights and argues for evidence-based, transparent and internationally aligned regulation that protects both animal welfare and the scientific value of preclinical research. new approach methodologies animal research strategic foresight scenarios trust in science competitiveness poskusne živali znanstvene raziskave etika tehnologija zaupanje v znanost true false true Angleški jezik Slovenski jezik Članek v reviji 2026-04-13 09:11:54 2026-04-13 09:12:00 2026-04-14 04:36:12 0000-00-00 00:00:00 2026 0 0 4 str. [article no.] 107001 Vol. 5 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2026-01-01 57.084 2772-4085 10.1016/j.nsa.2026.107001 274930691 RAZ_Heinla_Indrek_2026.htm RAZ_Heinla_Indrek_2026.htm 1 CEC663B72C890ECE171684C8BF4AFC05 2239470ca2c44a0f46b37a4115b0c796a021d8b7c2b5d3b5835a3b72a615d242 e97d338e-3707-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=232355 https://doi.org/10.1016/j.nsa.2026.107001 1 db1314e3-3707-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=232354 Biotehniška fakulteta 0 0 0