20.500.12556/RUL-181550 Heptanuclear zinc(II) complex with metronidazole synthesis, structure and antibacterial activity The reaction systems consisting of mononuclear zinc(II) acetate dihydrate, metronidazole (met) and nitrile solvent (acetonitrile or propionitrile) have afforded heptanuclear zinc(II) compounds, [Zn$_7$O$_2$(CH$_3$COO)$_{10}$(met)$_2$]∙2CH$_3$CN (1) and [Zn$_7$O$_2$(CH$_3$COO)$_{10}$(met)$_2$]∙2CH$_3$CH$_2$CN (2). Heptanuclear compounds 1 and 2 formed regardless of the reaction conditions: either under ambient conditions or when heated at 105 °C for 24 h in autoclaves. Their compositions were authenticated using single crystal X-ray crystallography. Both compounds feature the previously known {Zn$_7$O$_2$(CH$_3$COO)$_{10}$} structural core whose metal ions are interconnected via acetate and μ$_4$-oxide ligands. Two metronidazole ligands are coordinated to this core via imidazole nitrogen atoms. The zinc ions of the heptanuclear complex adopt different coordination environments: four are in nearly tetrahedral environments of four oxygen atoms, two are surrounded by NO$_4$ donor atoms which define vertices of a distorted square pyramid and one is in an octahedral environment of six oxygen atoms. The Znsingle bondO bonding patterns reflect both the nature and the number of donors. The solid-state structures of 1 and 2 display different intermolecular connectivities. Antibacterial testing against a series of Gram-positive and Gram-negative bacteria shows that [Zn$_7$O$_2$(CH$_3$COO)$_{10}$(met)$_2$]∙2CH$_3$CN (1) exhibits moderate activity against Staphylococcus epidermidis. Overall, the study advances the field of metal-based antimicrobial agents and offers new perspectives on addressing antibiotic resistance. Zinc(II) Zn$_4$(μ$_4$-O) entity heptanuclear core metronidazole crystal structure antibacterial activity cink(II) Zn$_4$(μ$_4$-O) entiteta heptanuklearno jedro metronidazol kristalna struktura antibakterijsko delovanje true false true Angleški jezik Slovenski jezik Članek v reviji 2026-04-10 09:51:02 2026-04-10 09:51:10 2026-04-13 04:41:46 0000-00-00 00:00:00 2026 0 0 8 str. Vol. 20, art. 102267 Feb. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 546.47:615.28 2211-7156 10.1016/j.rechem.2025.102962 262343683 RAZ_Modec_Barbara_2026.pdf RAZ_Modec_Barbara_2026.pdf 1 098E88AAA611D2F593334F15B3BBA8AE 18c41c2a4f3181be5ef680ebc38115ae7df61160f3d2cc4f69d19b4e3fe6c53d 215ca563-34b3-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=232187 https://www.sciencedirect.com/science/article/pii/S2211715625009464 1 d649cf0d-34b1-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=232184 Fakulteta za kemijo in kemijsko tehnologijo Fakulteta za farmacijo Veterinarska fakulteta 0 0 0