20.500.12556/RUL-181537 Sistematični pregled literature o učinkovitosti magnezija pri lajšanju glavobola Systematic literature review on the efficacy of magnesium in headache relief Magnezij je ključen kation, ki sodeluje v številnih fizioloških procesih, med drugim pri nastanku celične energije ter sintezi DNA in RNA. Med mehanizmi, ki so povezani s patofiziologijo migrenskih in tenzijskih glavobolov, izstopata predvsem njegova vloga pri regulaciji sinteze dušikovega oksida ter delovanju glutamatnega receptorja N‑metil‑D‑aspartata. Namen naloge je bil izvesti sistematični pregled literature o učinkovitosti magnezijevih soli pri lajšanju glavobola. Proučevani izidi so vključevali pogostost migrenskih dni, število migrenskih napadov, spremembo intenzitete bolečine ter pojavnost neželenih učinkov. Literaturo smo po vnaprej določenem iskalnem profilu poiskali v podatkovnih bazah PubMed in Web of Science ter sledili načelom PRISMA. Od 307 zadetkov smo v pregled vključili 25 raziskav. Pri peroralnih oblikah je večina randomiziranih raziskav pokazala zmanjšanje pogostosti in/ali intenzitete migrenskih napadov, medtem ko so rezultati kombinacij magnezija z drugimi učinkovinami nekonsistentni. Vse raziskave o intravenski aplikaciji magnezijevega sulfata so nakazale učinkovito lajšanje bolečine pri migreni z avro. Primerjave z drugimi učinkovinami večinoma ne ugotavljajo statistično značilnih razlik, vendar prinašajo ugotovitve, ki so lahko klinično pomembne. Za morebitno vključitev magnezijevih soli v klinično prakso bi potrebovali več randomiziranih, s placebom kontroliranih raziskav Magnesium is an essential cation involved in a wide range of physiological processes, including cellular energy production and the synthesis of DNA and RNA. Two of its roles are particularly relevant to the pathophysiology of migraine and tension‑type headaches: the regulation of nitric oxide synthesis and the modulation of the N‑methyl‑D‑aspartate receptor. The aim of this study was to systematically review the available literature on the effectiveness of magnesium salts in alleviating headache. Outcomes of interest included the frequency of migraine days, the number of migraine attacks, changes in pain intensity, and the occurrence of adverse effects. A structured search was conducted in the PubMed and Web of Science databases following a predefined search strategy and PRISMA guidelines. Of the 307 records identified, 25 studies met the inclusion criteria. Most randomized trials investigating oral magnesium formulations reported a reduction in the frequency and/or intensity of migraine attacks, whereas findings from studies combining magnesium with other active substances were inconsistent. All studies examining intravenous magnesium sulfate demonstrated effective pain relief in patients with migraine with aura. Comparisons with other therapeutic agents generally did not yield statistically significant differences, although some results may still hold clinical relevance. Overall, additional randomized, placebo‑controlled trials are needed before magnesium salts can be confidently integrated into routine clinical practice. magnezij migrena tenzijski glavobol bolečina magnesium migraine tension-type headache pain true false false [M. Klarič] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2026-04-10 08:45:06 2026-04-10 08:45:28 2026-05-05 11:04:24 0000-00-00 00:00:00 2026 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1970-01-01 615.3:546.24:616.857(043.2) 124986 275327235 31917.pdf 31917.pdf 1 CB2473AF27AD987DA9DD3BDA4DD49863 8d78147da29dbf97576976d6cfc89fd19b0d6a71ee07f5127978142e807a9a93 a9e603d5-34a8-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=232097 Fakulteta za farmacijo 0 0 0