20.500.12556/RUL-181506 Association between red blood cell transfusion and adverse clinical outcomes is independent of cardiac history a multicenter observational InPUT study analysis Purpose: Red-blood-cell (RBC) transfusion is one of the most frequent interventions in critical care patients. While patients with acute cardiac conditions are more likely to receive transfusions at higher haemoglobin thresholds than other critically ill patients, data on RBC transfusion practice for critically ill patients with pre-existing cardiac conditions are scarce. Methods: Using the International Point-Prevalence Study of Intensive-Care Unit Transfusion Practices cohort, weighted logistic regression investigated the association between the RBC units transfused and the primary composite outcome of 28-day mortality, new-onset acute kidney injury or ventilatory weaning failure. Interactions with cardiac history (acute coronary syndrome and/or heart failure) were tested. Results: Cardiac history was present in 746 of 3643 patients (20%) and 894 of 3643 (25%) received at least one RBC unit. Transfusion rates were similar in patients with and without cardiac history (25% vs. 24%; p = 0.51). Among transfused patients, median nadir haemoglobin during ICU stay was slightly higher in those with cardiac history (7.6 g/dL vs. 7.4 g/dL respectively; p = 0.007), whereas stated haemoglobin transfusion threshold did not statistically differ (8.5 g/dL vs. 8.0 g/dL; p = 0.11). Each additional RBC unit increased the odds of the composite outcome in the whole cohort (2.18, 95% CI 1.85–2.56, p < 0.0001), without interaction with cardiac history (p = 0.44). Conclusions: RBC transfusion was commonly and similarly prescribed in critically ill patients with or without cardiac history. Each additional unit was associated with a worse outcome with no evidence of differential effect due to cardiac history. red blood cell transfusion intensive care units critical care heart failure true false true Angleški jezik Ni določen Članek v reviji 2026-04-09 10:48:13 2026-04-09 10:48:15 2026-05-20 08:40:35 0000-00-00 00:00:00 2025 0 0 12 str. art. 526 Vol. 29 Dec. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 1466-609X 10.1186/s13054-025-05745-5 263428611 RAZ_Kimmoun_Antoine_2025.pdf RAZ_Kimmoun_Antoine_2025.pdf 1 4B8A2FC0DC59D409D5B8B60485F6632B b20f768e7dbb349feb093c386586982c15f866437c8a978e293a1f03f1dc7848 bb701000-33f5-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=232028 https://link.springer.com/article/10.1186/s13054-025-05745-5 1 b8c99f33-33f0-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=232024 Medicinska fakulteta 0 0 0