20.500.12556/RUL-181494 CAR T therapy in adult DLBCL patients in Slovenia evaluation of predictive scores for outcomes and adverse events CAR T cell therapy is a promising immunotherapy for hematologic malignancies, yet early prediction of outcomes and adverse events remains difficult, especially in small real-world cohorts. We retrospectively analyzed 14 adult patients with diffuse large B-cell lymphoma (DLBCL) treated with CAR T cells in Slovenia, assessing IL-6 increase rates and established predictive metrics including EASIX-C, CAR-HEMATOTOX, and IBPS on Day −5 (pre-lymphodepletion) and Day 0 (infusion). Contrary to our expectation, an inverse correlation was observed between the increase rate of IL-6 and the occurrence of severe cytopenias, indicating higher IL-6 increase rate leads to less severe cytopenias. The EASIX-C score showed higher predictive values when calculated on Day 0, contrary to the CAR-HEMATOTOX score, whose higher predictive values were observed on Day −5. The IBPS predictive values showed mixed results when comparing Day −5 to Day 0. We observed 50% response rate and 29% remission rate. The results highlight the utility of predictive scores, with unexpected findings on IL-6 suggesting further study is necessary. CAR T cell therapy hematologic malignancies diffuse large B-cell lymphoma predictive scores adverse events therapeutic outcomes celično zdravljenje CAR T hematološke maligne bolezni difuzni velikocelični limfom neželeni učinki true false true Angleški jezik Slovenski jezik Članek v reviji 2026-04-09 04:56:55 2026-04-09 08:29:22 2026-06-03 10:19:33 0000-00-00 00:00:00 2026 0 0 12 str. no. 1, art. 2620889 Vol. 22 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2164-5515 10.1080/21645515.2026.2620889 267251459 RAZ_Levstek_Lucija_2026.pdf RAZ_Levstek_Lucija_2026.pdf 1 53B82CDDF44A9AD52C8A607F1AEC051E 86a409e8e99a625f2275692f7ddc0ff0bba2b61205a6d5d8c92f2c15a4138fd5 1be155fd-33e2-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=232016 https://www.tandfonline.com/doi/full/10.1080/21645515.2026.2620889 1 93655a9b-33bf-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=232005 Medicinska fakulteta 0 0 0