20.500.12556/RUL-181333 Model-based design of a microfluidic pervaporation device for intensified VOC separation research data underlying the article Downstream separation remains a major bottleneck in the development of continuous bioprocesses, particularly in the removal of volatile organic by-products such as acetone and acetophenone. Here we present a novel microfluidic pervaporation device developed for efficient VOC extraction from aqueous media under steady-state conditions. The system integrates a 3D-printed channel architecture with a PDMS membrane and leverages a first-principles mathematical model that does not require customised parameters. Experimental validation with acetone–water and acetophenone-buffer mixtures demonstrated excellent separation performance with a separation efficiency of over 97 %. A detailed time scale analysis confirmed that membrane diffusion is the dominant transport resistance, guiding optimization strategies toward geometric design and membrane material selection. The predictive power of the developed mathematical model enabled a rational tuning of geometry and flow conditions, while the modular fabrication approach ensures adaptability and scalability. This work highlights the potential of combining microfluidics, modeling and additive manufacturing to intensify separations and enable seamless integration into upstream biocatalytic or pharmaceutical production systems microfluidic pervaporation volatile organic compounds process intensification mathematical modeling continuous separation mikrofluidna pervaporacija hlapne organske spojine intenzifikacija procesov matematično modeliranje kontinuirno ločevanje true false false Angleški jezik Slovenski jezik Neznano 2026-04-01 21:52:27 2026-04-01 22:02:32 2026-04-27 10:47:29 0000-00-00 00:00:00 2025 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 README.txt README.txt README 1 C86D3209484013F241C4DB955C7AF6A7 b2f387daa40ae45455bf0c817ae7b207c141dbe0a1a058710d225f3804dccaf6 8dece172-2f25-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=231761 HPLC_REPORT.zip HPLC_REPORT.zip HPLC Report 1 61816A4155F151C12765A679D8698FED a9153140dd00224839329c2c53777017a9db32a66af0e7f239f06fe87d519a0b 7f2fc484-2e05-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=231708 Results-pervaporation.xlsx Results-pervaporation.xlsx Results pervaporation 1 6C2A9DE30A6BFEB89CFBB258826C3B10 b58379904264444e3c854824f5ccff7441549969606d8c2bb3d377353b0387f2 9202edce-2e06-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=231709 Fakulteta za kemijo in kemijsko tehnologijo Meritve in testi 0 0 0