20.500.12556/RUL-180890 Klinična in radiološka ocena zdravljenja tendinoze supraspinatusa s pripravkom plazme, obogatene s trombociti Clinical and radiologic evaluation of treatment of supraspinatus tendinosis with platelet rich plasma infiltration Uvod: Kvantitativne tehnike slikanja z magnetno resonanco, kot je kartiranje relaksacijskega časa T2, omogočajo zaznavanje zgodnjih sprememb v tetivah po bioloških terapijah. Namen raziskave je bil oceniti strukturno preoblikovanje tetive supraspinatusa z uporabo merjenja povprečnih relaksacijskih časov T2 in profilov porazdelitve relaksacijskega časa T2 po enkratnem ultrazvočno vodenem injiciranju plazme obogatene s trombociti. Metode: V raziskavo je bilo vključenih 26 bolnikov s simptomatsko tendinopatijo tetive supraspinatusa, ki so bili razdeljeni v skupini s tendinozo (n = 9) in delno rupturo (n = 13) tetive. Opravljeni so bili T2 kartiranje, klinično ocenjevanje bolnikov s pomočjo vprašalnikov SPADI in Constant-Murleyjev indeksom pred zdravljenjem in šest mesecev po PRP terapiji. Povprečne T2 vrednosti so bile izmerjene v lateralnem, srednjem in medialnem segmentu tetive supraspintusa. Primerjali smo T2 profile vključenih bolnikov in asimptomatskih preiskovancev za referenčno kontrolo. Rezultati: Klinični izidi so pokazali statistično značilno izboljšanje v obeh skupinah (tendinoza in delna ruptura) šest mesecev po zdravljenju. Povprečni T2 relaksacijski časi po PRP zdravljenju niso pokazali pomembnih sprememb med analiziranimi segmenti tetive. Analiza porazdelitve T2 je razkrila statistično značilne spremembe pri obeh zdravljenih skupinah. V skupini s tendinozo so se T2 profili po terapiji približali T2 profilom pri asimptomatskih preiskovancih, kar kaže na strukturno preoblikovanje skladno s procesom celjenja tetive. Zaključki: T2 kartiranje se je izkazalo kot učinkovito orodje za zaznavanje preoblikovanja tetive supraspinatusa po terapiji s PRP. Strukturne izboljšave tetive, ki kažejo na celjenje tkiva, so bile opažene pri tendinozi, ne pa pri delnih rupturah tetive. Rezultati podpirajo uporabo T2 kartiranja, zlasti profiliranje porazdelitve T2 relaksacijskega časa, kot kvantitativnega biomarkerja za oceno odziva na zdravljenje s PRP. Introduction: Quantitative magnetic resonance imaging techniques, such as T2 relaxation time mapping, allow for the detection of early tendon alterations following biological therapies. This study aimed to assess structural remodeling of the supraspinatus tendon by analyzing mean T2 relaxation times and T2 relaxation time distribution profiles after a single ultrasound-guided injection of platelet-rich plasma. Methods: A total of 26 patients with symptomatic supraspinatus tendinopathy were enrolled and divided into two groups: tendinosis (n = 9) and partial tear (n = 13). T2 mapping and clinical evaluations were conducted using the Shoulder Pain and Disability Index (SPADI) and the Constant-Murley score, both prior to treatment and six months post-PRP injection. Mean T2 values were measured in the lateral, middle, and medial segments of the supraspinatus tendon. The T2 profiles of patients were compared with those of asymptomatic volunteers for reference. Results: Clinical outcomes demonstrated a statistically significant improvement in both groups six months after treatment. Mean T2 values showed no significant changes across the tendon segments following PRP therapy. However, analysis of T2 distribution profiles revealed statistically significant differences in both groups. In the tendinosis group, post-treatment T2 profiles closely resembled those of asymptomatic individuals, indicating structural remodeling consistent with tendon healing. Conclusions: T2 mapping proved to be a sensitive tool for detecting supraspinatus tendon remodeling after PRP therapy. Structural improvements indicative of tissue healing were observed in the tendinosis group but not in the partial tear group. These findings support the utility of T2 mapping—especially T2 distribution profiling—as a quantitative biomarker for evaluating the therapeutic response to PRP treatment. T2 kartiranje PRP tendinopatija supraspinatusa MR T2 mapping PRP supraspinatus tendinopathy magnetic resonance imaging true false false Slovenski jezik Angleški jezik Doktorsko delo/naloga 2026-03-19 07:16:27 2026-03-19 07:16:37 2026-03-22 03:54:18 0000-00-00 00:00:00 2026 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1970-01-01 38967 8372.pdf 8372.pdf 1 FA80CE39A820F126AF503CA8CEB68304 c2715de4abc9c9fce093fb76a12df033fc68149e34ae5713ebf8ae6cf46f3bd3 1a92fc96-235b-11f1-b0ab-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=230833 Medicinska fakulteta 0 0 0