20.500.12556/RUL-179994 Reduced cardiovascular mortality at moderate altitude a putative role of physical activity and body mass Epidemiological evidence suggests that living at a moderate altitude (i.e. between 1000 and 2500 m) is associated with lower overall mortality, particularly from cardiovascular diseases. The underlying mechanisms have been scarcely investigated, although environmental and lifestyle factors likely play prominent roles. This review aims to shed light on two important modulators of cardiovascular health and mortality, that is, physical activity and body mass, and to explore how these factors interact with altitude. The lifestyle habits of people living at moderate altitudes have been shown to differ from individuals living at low altitudes. In addition the environmental conditions, notably the hypobaric hypoxia, at moderate altitudes influence the physiological parameters associated with these habits. Specifically engaging in the same physical activity at moderate altitude compared to low altitude results in enhanced cardiovascular responses and specific metabolic responses, potentially imparting benefits related to the cardiovascular system and body composition. Conversely mild hypobaric hypoxia can suppress appetite and food intake, leading to lower overall body mass and decreased risk of obesity. Exercise or sleep can accentuate the hypoxic stimuli at moderate altitudes and, like hypoxia conditioning, elicit adaptations such as improved oxygen supply, reduced dependence on oxygen and increased cellular/tissue resilience. These effects may prove beneficial for the cardiovascular and metabolic systems and contribute to lower mortality rates observed in moderate altitude residents. ageing body mass cardiovascular diseases exercise health moderate altitude physiology physical activity srčno-žilne bolezni umrljivost zmerna nadmorska višina telesna dejavnost telesna masa true false true Angleški jezik Slovenski jezik Članek v reviji 2026-02-27 12:44:19 2026-02-27 12:44:20 2026-04-15 11:44:03 0000-00-00 00:00:00 2025 0 0 Str. 1-18 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 796.01 1469-7793 10.1113/JP290022 256219907 2026_Mallet-et-al-JP.pdf 2026_Mallet-et-al-JP.pdf 1 720A81C93E0EC13B9F39ECB9A5908EA0 ea6d3faa643f553f06fec4c27c24319d0921e81ebf8020f686ee9b33fc7a13d8 5d6287d3-13d1-11f1-a1ba-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=228986 https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP290022 1 531c1b94-13d1-11f1-a1ba-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=228985 Fakulteta za šport 0 0 0