20.500.12556/RUL-179033 Photoinduced ring-opening polymerization of N-carboxyanhydrides for the preparation of cross-linked polypeptide gels Using light to activate chemical reactions is a powerful approach that allows spatiotemporal control over physicochemical transformations, commonly used in the polymerization and solidification of reactive liquids. Here, we employ a photochemical approach for ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydride (NCA) monomers to prepare covalently cross-linked synthetic polypeptide gels using light. We apply 2-nitrobenzyl carbamate as a photocaged amine (base), where the switch in its activity after illumination is a key factor in controlling ROP. The released dibutylamine, as a basic species, can deprotonate the NCA and thereby initiate polymerization. We investigate the effects of 2-nitrobenzyl dibutyl carbamate on γ-benzyl-L-glutamate NCA polymerization and apply this approach to prepare covalently cross-linked polypeptide gels. We demonstrate excellent 2D spatiotemporal control over gelation, further enhanced by the use of an acid inhibitor that prevents overcuring caused by diffusion of active species from the illuminated region. The development of photoinduced polymerization and cross-linking of NCAs offers significant advantages in polypeptide synthesis and holds great potential for further applications in additive manufacturing. N-carboxyanhydride photobase photochemistry polypeptide gel ring-opening polymerization true false true Angleški jezik Ni določen Članek v reviji 2026-02-03 15:46:33 2026-02-03 15:46:34 2026-02-05 03:45:55 0000-00-00 00:00:00 2026 0 0 7 str. iss. 6, art. e21891 Vol. 65 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 54 1521-3773 10.1002/anie.202521891 264264963 Angew_Chem_Int_Ed_-_2025_-_Kocman_-_Photoinduced_Ring‐Opening_Polymerization_of_N‐Carboxyanhydrides_for_the_Preparation_of.pdf Angew_Chem_Int_Ed_-_2025_-_Kocman_-_Photoinduced_Ring‐Opening_Polymerization_of_N‐Carboxyanhydrides_for_the_Preparation_of.pdf 1 736B16E22328E0E15DC8DA88C9DAEF43 8d1d8c243ea0a385f60df1c8ec2599607e3f05ec464ee1d186fb5afab3c88501 9df448f7-010f-11f1-a1ba-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=227127 https://onlinelibrary.wiley.com/doi/10.1002/anie.202521891 1 1013fe5a-010f-11f1-a1ba-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=227126 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0