20.500.12556/RUL-178482 Secondary findings in hereditary cancer genes after germline genetic testing systematic review of literature In the last decade the increasing use of germline genetic testing has led to frequent discoveries of secondary findings (SF) in hereditary cancer (HC) genes. Disclosure and clinical management of such findings are still not clearly defined and raise many ethical, clinical, and practical questions. This systematic review is focused on frequency of reported SF in HC genes across different populations as well as summarizing current guidelines, recommendations, and actual clinical practice about reporting and managing SF in HC genes. A systematic literature search according to the PRISMA guidelines was performed on the electronic database PubMed from inception to June 2024. 30 research papers involving almost 150,000 patients were reviewed. The reported frequencies of SF in HC genes varied between 0.4 and 3.1%. The majority of patients agreed to receive SF for medically actionable genes. Management and surveillance of patients after disclosure of SF in HC genes were rarely reported, but the limited data show no regret of receiving such results as well as diagnoses of early-stage cancer in patients participating in recommended surveillance programs related to SF. A substantial number of carriers of highly penetrant pathogenic variants in HC genes is discovered by reporting SF after germline genetic testing with next-generation sequencing. Additional information about the impact of SF disclosure on individuals and health care systems is needed to optimize the integration of SF into clinical care. hereditary cancer genetic testing systematic review dedni raki genetski testi sistematični pregled true false true Angleški jezik Slovenski jezik Članek v reviji 2026-01-28 15:15:25 2026-01-28 15:15:29 2026-01-30 04:15:58 0000-00-00 00:00:00 2025 0 0 Str. 595–604 iss. 6 Vol. 144 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-07 0340-6717 10.1007/s00439-025-02746-w 235578627 s00439-025-02746-w.pdf s00439-025-02746-w.pdf 1 60E37D6E4F1156EF3FD6429059022A99 faa76a99be3d8ad53af6c06e9dbd5d18c8347a87e2cb20a0c9aa78d4e4e1284a cbafb039-fc54-11f0-a1ba-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=226386 https://link.springer.com/article/10.1007/s00439-025-02746-w 0 871a2892-fc54-11f0-a1ba-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=226385 Medicinska fakulteta 0 0 0