20.500.12556/RUL-178465 Fatty acid and amino acid derivatives in organocatalyzed Michael additions Amino acid derivatives, such as β-keto esters and pyrrolones, were used as nucleophiles in organocatalyzed Michael additions to nitroalkene acceptors, while fatty acid derivatives acted as both nucleophiles (β-keto esters) and electrophiles (nitroalkene acceptors). Bifunctional noncovalent organocatalysts were employed as asymmetric organocatalysts. Twenty compounds—including fatty acid and amino acid derivatives, as well as fatty acid–amino acid conjugates—were prepared with enantioselectivities of up to 98% ee. All novel products were fully characterized. This research demonstrates the ease of assembling readily available fatty acid and amino acid building blocks under ambient conditions. fatty acids amino acids keto esters pyrrolones nitroalkene acceptors Michael addition asymmetric organocatalysis enantioselectivity diastereoselectivity tetronic acid maščobne kisline aminokisline keto estri piroloni akceptorji nitroalkenov Michaelova adicija asimetrična organokataliza enantioselektivnost diastereoselektivnost tetronska kislina true false true Angleški jezik Slovenski jezik Članek v reviji 2026-01-28 09:02:30 2026-01-28 09:02:31 2026-01-30 04:02:39 0000-00-00 00:00:00 2026 0 0 29 str. iss. 2, art. 204 Vol. 31 Jan. 2026 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 547.466 1420-3049 10.3390/molecules31020204 263788803 RAZ_Flis_Aljaz_2026.pdf RAZ_Flis_Aljaz_2026.pdf 1 0489DD4735480D927120833D2FD7EFFB 8f1f715e0ac41f449d802d2495ffe94aaba409e09c57a773905004038c947af5 096292f5-fc20-11f0-a1ba-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=226352 https://www.mdpi.com/1420-3049/31/2/204 1 ac90c029-fc1f-11f0-a1ba-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=226351 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0