20.500.12556/RUL-178430 The impact of histopathology on prognosis of squamous cell carcinoma of the larynx can we do better? Despite decades of progress, laryngeal squamous cell carcinoma (SCC) is still associated with significant morbidity and mortality worldwide. Additional biomarkers are needed to apply precision medicine and predict the clinical course. We reviewed and summarised routinely reported histopathologic features (e.g. subtypes of laryngeal SCC) along with promising potential biomarkers not yet routinely assessed using international guidelines. These include extra- vs intratumoural vascular and perineural invasion, tumour budding, depth of invasion, and tumour-infiltrating lymphocytes. We also address the problem of specimen quality and type (open approach vs endoscopic surgery) and the related limitations. High-risk human papillomavirus infection is another controversial issue to be discussed, being rare in laryngeal SCC, with an indeterminate prognostic significance and less reliable p16 overexpression as a surrogate marker of HPV infection. Further studies are warranted to address the applicability and to see which of the described parameters may help to better stratify patients with laryngeal SCC and should therefore be included in the pathology report. larynx biomarkers disease progression human papillomavirus lymphocytes tumour-infiltrating morbidity precision medicine prognosis squamous cell carcinoma larinks grlo biološki označevalci napredovanje bolezni humani papiloma virus HPV limfociti infiltracija tumorja obolevnost precizna medicina ploščatocelični karcinom true false true Angleški jezik Slovenski jezik Članek v reviji 2026-01-27 15:30:48 2026-01-27 15:30:52 2026-01-28 04:29:14 0000-00-00 00:00:00 2025 0 0 Str. 13–32 iss. 1 Vol. 487 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 0945-6317 10.1007/s00428-025-04082-w 232364035 s00428-025-04082-w.pdf s00428-025-04082-w.pdf 1 7AF4A238357051DFE595D1A5BA333476 3a597364879042137685fcac1fee72f57140ac8e9933fc6245caab9b60e30a8e 53dd6ee6-fb8d-11f0-a1ba-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=226308 https://link.springer.com/article/10.1007/s00428-025-04082-w 1 c5aab398-fb8c-11f0-a1ba-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=226303 Medicinska fakulteta 0 0 0