20.500.12556/RUL-178196 Complement cascades and brain disorders The complement system is a vital component of innate immunity. Besides its roles in pathogen defense, its significance in neurodevelopment, neurodegeneration, and cancer progression is beginning to be recognized. We performed a comprehensive literature review to summarize the involvement and dysregulation of the complement system in three main CNS-associated conditions: Alzheimer's disease, schizophrenia, and glioma. In Alzheimer's disease, activation of the complement system contributes to neuroinflammation, synaptic loss, and neuronal death. In glioblastoma, complement promotes tumor growth, immune evasion, and therapy resistance. In schizophrenia, genetic variations in complement components, particularly C4A, are associated with synaptic pruning abnormalities and disease susceptibility. We conclude that the complement system has a dual role of protector and pathogenic mediator in the central nervous system. While it is critical in neurodegenerative, oncological, and psychiatric disorders, its role is not understood well enough. For therapeutic purposes, targeting the complement system may open new frontiers for therapeutic interventions without disrupting important physiological processes. More research is needed to elucidate the exact roles of the complement and help translate these findings into clinical settings. complement system humoral immunity immune system innate immunity neurodegeneration neurology oncology psychiatric disorders sistem komplementa homoralna imunost imunski sistem prirojena imunost nevrodegeneracija nevrologija onkologija psihiatrične motnje true false true Angleški jezik Slovenski jezik Članek v reviji 2026-01-21 10:09:34 2026-01-21 10:09:38 2026-01-22 04:36:25 0000-00-00 00:00:00 2025 0 0 21 str. iss. 8, art. 1179 Vol. 15 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 2218-273X 10.3390/biom15081179 248447747 RAZ_Jovchevska_Ivana_2025.pdf RAZ_Jovchevska_Ivana_2025.pdf 1 DCDBF955C3BDE0EF0C420BEEE9F6E08D f16560fd3ee66a9d3af65a422fc00bc94473e02c55e8241a55cc4338dd585272 bc54d8d5-f6c6-11f0-bf92-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=225835 https://www.mdpi.com/2218-273X/15/8/1179 1 da418bc5-f6a8-11f0-bf92-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=225794 Medicinska fakulteta 0 0 0